Recombinant Human DSG1
Cat.No. : | DSG1-26581TH |
Product Overview : | Recombinant full length Human Desmoglein 1 with N terminal proprietary tag; Predicted MWt 142.39 kDa inclusive of tag. |
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Description : | Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus. |
Protein length : | 1049 amino acids |
Molecular Weight : | 142.390kDa inclusive of tags |
Source : | Wheat germ |
Tissue specificity : | Epidermis, tongue, tonsil and esophagus. |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage buffer : | pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | MDWSFFRVVAMLFIFLVVVEVNSEFRIQVRDYNTKNGTIK WHSIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAAN QQVTYRISGVGIDQPPYGIFVINQKTGEINITSIVDREVT PFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMA TFAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIR QEPSDSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGS DRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQE NTLNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEI EMNERTNVGILKVVKPLDYEAMQSLQLSIGVRNKAEFHHS IMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGS NDKVGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTG KLTLKNKVTKEQYNMLGGKYQGTILSIDDNLQRTCTGTIN INIQSFGNDDRTNTEPNTKITTNTGRQESTSSTNYDTSTT STDSSQVYSSEPGNGAKDLLSDNVHFGPAGIGLLIMGFLV LGLVPFLMICCDCGGAPRSAAGFEPVPECSDGAIHSWAVE GPQPEPRDITTVIPQIPPDNANIIECIDNSGVYTNEYGGR EMQDLGGGERMTGFELTEGVKTSGMPEICQEYSGTLRRNS MRECREGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLI YDIEGVGSPAGSVGCCSFIGEDLDDSFLDTLGPKFKKLAD ISLGKESYPDLDPSWPPQSTEPVCLPQETEPVVSGHPPIS PHFGTTTVISESTYPSGPGVLHPKPILDPLGYGNVTVTES YTTSDTLKPSVHVHDNRPASNVVVTERVVGPISGADLHGM LEMPDLRDGSNVIVTERVIAPSSSLPTSLTIHHPRESSNV VVTERVIQPTSGMIGSLSMHPELANAHNVIVTERVVSGAG VTGISGTTGISGGIGSSGLVGTSMGAGSGALSGAGISGGG IGLSSLGGTASIGHMRSSSDHHFNQTIGSASPSTARSRIT KYSTVQYSK |
Sequence Similarities : | Contains 4 cadherin domains. |
Gene Name : | DSG1 desmoglein 1 [ Homo sapiens ] |
Official Symbol : | DSG1 |
Synonyms : | DSG1; desmoglein 1; DSG; desmoglein-1; CDHF4; |
Gene ID : | 1828 |
mRNA Refseq : | NM_001942 |
Protein Refseq : | NP_001933 |
MIM : | 125670 |
Uniprot ID : | Q02413 |
Chromosome Location : | 18q12.1 |
Pathway : | Apoptosis, organism-specific biosystem; Apoptotic cleavage of cell adhesionproteins, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem; Staphylococcus aureus infection, organism-specific biosystem; |
Function : | calcium ion binding; gamma-catenin binding; toxin binding; |
Products Types
◆ Recombinant Protein | ||
DSG1-1388H | Recombinant Human DSG1 Protein, His-tagged | +Inquiry |
DSG1-4389H | Recombinant Human DSG1 Protein, His (Fc)-Avi-tagged | +Inquiry |
DSG1-2890H | Recombinant Human DSG1 Protein, GST-tagged | +Inquiry |
DSG1-1794H | Recombinant Human DSG1 protein(50-609aa), His-tagged | +Inquiry |
DSG1-2820H | Recombinant Human DSG1 protein(391-540 aa), C-His-tagged | +Inquiry |
◆ Lysates | ||
DSG1-512HCL | Recombinant Human DSG1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionVarious factors, including cytokines and growth factors, can regulate the expression of DSG1 in skin cells.
Some clinical trials may be exploring DSG1-based therapies for skin disorders, but you should consult clinical trial databases for specific information.
DSG1 abnormalities are primarily linked to skin disorders, but some studies suggest potential connections to oral mucosa disorders.
While DSG1 is not a direct biomarker for skin cancer, its expression levels may be altered in some skin cancers.
Research is ongoing, but DSG1-targeted therapies have the potential to treat conditions related to DSG1 deficiencies.
Customer Reviews (3)
Write a reviewIts impeccable purity and integrity make it a valuable asset in my research endeavors.
Their team of experts has been instrumental in resolving any queries or challenges I encountered regarding the application and utilization of the DSG1 protein.
The DSG1 protein surpasses expectations in terms of quality and is an ideal match for my experimental requirements.
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