Recombinant Human ERCC6

• Cat.No.: ERCC6-26417TH
• Product Overview: Recombinant fragment of Human CSB with a N terminal proprietary tag: predicted molecular weight 36.63 kDa inclusive of tag.

Specification

• Description: This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The protein has ATP-stimulated ATPase activity; there are contradictory publications reporting presence or absence of helicase activity. The protein appears to interact with several transcription and excision repair proteins, and may promote complex formation at repair sites. Mutations in this gene result in Cockayne syndrome type B.
• Protein length: 100 amino acids
• Molecular Weight: 36.630kDa inclusive of tags
• Source: Wheat germ
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: RARNHLILPERLESESGHLQEASAL LPTTEHDDLLVEMRNFIAFQAHTDG QASTREILQEFESKLSASQSCVFRE LLRNLCTFHRTSGGEGIWKLKPEYC
• Sequence Similarities: Belongs to the SNF2/RAD54 helicase family.Contains 1 helicase ATP-binding domain.Contains 1 helicase C-terminal domain.

Gene Information

• Gene Name: ERCC6 excision repair cross-complementing rodent repair deficiency, complementation group 6 [ Homo sapiens ]
• Official Symbol: ERCC6
• Synonyms: ERCC6; excision repair cross-complementing rodent repair deficiency, complementation group 6; CKN2; DNA excision repair protein ERCC-6; Cockayne syndrome B protein; CSB; RAD26
• Gene ID: 2074
• mRNA Refseq: NM_000124
• Protein Refseq: NP_000115
• MIM: 609413
• Uniprot ID: Q03468
• Chromosome Location: 10q11
• Pathway: DNA Repair, organism-specific biosystem; Dual incision reaction in TC-NER, organism-specific biosystem; Formation of transcription-coupled NER (TC-NER) repair complex, organism-specific biosystem; Nucleotide Excision Repair, organism-specific biosystem; Nucleotide excision repair, organism-specific biosystem
• Function: ATP binding; DNA binding; NOT DNA helicase activity; DNA-dependent ATPase activity; chromatin binding