Recombinant Mouse Ercc6 Protein, His-tagged

• Cat.No.: Ercc6-1435M
• Product Overview: Recombinant Mouse Ercc6 Protein (Gln13-Tyr179) with N-His tag was expressed in E. coli.

Specification

• Description: Predicted to enable several functions, including ATP binding activity; protein C-terminus binding activity; and protein tyrosine kinase activator activity. Acts upstream of or within several processes, including intracellular signal transduction; nucleic acid metabolic process; and photoreceptor cell maintenance. Predicted to be located in nuclear body; nucleolus; and site of DNA damage. Predicted to be part of transcription elongation factor complex. Predicted to be active in nucleus. Is expressed in genitourinary system. Used to study Cockayne syndrome. Human ortholog(s) of this gene implicated in several diseases, including Cockayne syndrome (multiple); De Sanctis-Cacchione syndrome; UV-sensitive syndrome; age related macular degeneration 5; and primary ovarian insufficiency 11. Orthologous to human ERCC6 (ERCC excision repair 6, chromatin remodeling factor).
• Source: E. coli
• Species: Mouse
• Tag: N-His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 21.8 kDa
  Accurate Molecular Mass: 32 kDa
• Protein length: Gln13-Tyr179
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: Ercc6 excision repair cross-complementing rodent repair deficiency, complementation group 6 [ Mus musculus (house mouse) ]
• Official Symbol: Ercc6
• Synonyms: ERCC6; excision repair cross-complementing rodent repair deficiency, complementation group 6; DNA excision repair protein ERCC-6; CS group B correcting; CSB; 4732403I04; C130058G22Rik
• Gene ID: 319955
• mRNA Refseq: NM_001081221
• Protein Refseq: NP_001074690
• UniProt ID: F8VPZ5