Recombinant Human ERMAP, His-tagged

• Cat.No.: ERMAP-7771H
• Product Overview: Recombinant Human Erythroid MembraneAssociated Protein/ERMAP produced by transfected human cell is a secreted protein with sequence (His30Ala155) of Human ERMAP fused with a polyhistidine tag at the Cterminus.

Specification

• Description: Human Erythroid MembraneAssociated Protein (ERMAP) is a cell surface transmembrane protein that belongs to the immunoglobulin superfamily. It is hghly expressed in bone marrow and to a lower extent in leukocytes, thymus, lymph node and spleen. ERMAP contains 1 B30.2/SPRY domain and 1 Iglike Vtype (immunoglobulinlike) domain. It may serve as an erythroid cell receptor, possibly as a mediator of cell adhesion. ERMAP is responsible for the Scianna/Radin blood group system. Two transcript variants encoding the same protein have been found for this gene ERMAP.
• Source: HEK293 Cells
• Species: Human
• Tag: His
• Form: Lyophilized from a 0.2 μM filtered solution of 20mM PB, 150mM NaCl, pH 7.2
• AA Sequence: HAGDAGKFHV ALLGGTAELL CPLSLWPGTV PKEVRWLRSP FPQRSQAVHI FRDGKDQDED LMPEYKGRT VLVRDAQEGS VTLQILDVRL EDQGSYRCLI QVGNLSKEDT VILQVAAPSV G SLSPSAVD HHHHHH*
• Purity: Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
• Notes: For research use only.
• Storage: Lyophilized protein should be stored at less than 20°C. though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C. for 2-7 days.Aliquots of reconstituted samples are stable at less than 20°C. for 3 months.

Gene Information

• Gene Name: ERMAP erythroblast membrane-associated protein (Scianna blood group) [ Homo sapiens ]
• Official Symbol: ERMAP
• Synonyms: ERMAP; erythroblast membrane-associated protein (Scianna blood group); erythroblast membrane associated protein , erythroblast membrane associated protein (RD and SC blood groups) , Radin blood group , RD, SC, Scianna blood group; erythroid membrane-associated protein; Radin blood group (Rd); Scianna blood group (Sc); radin blood group antigen; scianna blood group antigen; RD; SC; PRO2801; MGC118810; MGC118811; MGC118812; MGC118813
• Gene ID: 114625
• mRNA Refseq: NM_001017922
• Protein Refseq: NP_001017922
• MIM: 609017
• UniProt ID: Q96PL5
• Chromosome Location: 1p34

Reviews

11/27/2020

Their prompt and effective responses help ensure smooth and efficient progress, indeed solving any problem that arises.

10/02/2016

The knowledgeable and experienced support team is readily available to address any questions or concerns that researchers may have throughout their experimental journey.

07/02/2016

Its stability and reliability warrant its inclusion in my research protocols, leading to meaningful and conclusive results.

Q&As

Are there any ongoing clinical trials related to ERMAP protein and anemia?

Clinical trials investigating the role of ERMAP protein in anemia and potential therapeutic interventions are currently underway, aiming to advance our understanding and develop new treatment options.

What are the diagnostic implications of ERMAP mutations in anemia?

ERMAP mutations can be identified through genetic testing, which can aid in the diagnosis and classification of anemia, as well as guide treatment strategies.

How does ERMAP protein contribute to the regulation of iron metabolism?

ERMAP protein may play a role in the regulation of iron uptake and utilization by red blood cells, which is critical for the maintenance of normal hemoglobin levels and prevention of iron-deficiency anemia.

How is ERMAP protein involved in the etiology of anemia?

ERMAP protein is essential for the proper development and maturation of red blood cells. Mutations in the ERMAP gene can lead to various types of anemia, such as hereditary spherocytosis.

How does ERMAP protein contribute to the pathophysiology of hemolytic anemia?

ERMAP protein is involved in maintaining the structural integrity of red blood cells, and mutations in the ERMAP gene can lead to hemolytic anemia due to increased fragility and destruction of red blood cells.