Recombinant Human FBN1 protein, GST-tagged

• Cat.No.: FBN1-1883H
• Product Overview: Recombinant Human FBN1 protein(783-850 aa), fused with GST tag, was expressed in E.coli.

Specification

• Source: E.coli
• Species: Human
• Tag: GST
• Form: The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8.). 5 % trehalose and 5 % mannitol are added as protectant before lyophilization. The elution buffer contain 100mM GSH.
• Protein Length: 783-850 aa
• AA Sequence: NTPGSFVCTCPKGFIYKPDLKTCED IDECESSPCINGVCKNSPGSFICEC SSESTLDPTKTICIETIK
• Purity: 85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
• Storage: Short-term storage: Store at 2-8°C for (1-2 weeks).
  Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles.
• Reconstitution: Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage.
  Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage.

Gene Information

• Gene Name: FBN1 fibrillin 1 [ Homo sapiens ]
• Official Symbol: FBN1
• Synonyms: FBN1; fibrillin 1; FBN, fibrillin 1 (Marfan syndrome) , MFS1, WMS; fibrillin-1; Marfan syndrome; MASS; OCTD; SGS; fibrillin 15; FBN; WMS; MFS1; SSKS; WMS2; ACMICD; GPHYSD2
• Gene ID: 2200
• mRNA Refseq: NM_000138
• Protein Refseq: NP_000129
• MIM: 134797
• UniProt ID: P35555

Reviews

10/12/2022

Excellent in cell culture functionality

05/03/2020

Exceptional specificity in immunohistochemistry

04/14/2020

Highly stable and reliable in assays

Q&As

What potential therapeutic applications arise from targeting FBN1 in connective tissue disorders?

Targeting FBN1 offers potential for treating connective tissue disorders by restoring matrix integrity and function.

How do genetic variations in FBN1 affect connective tissue disorders?

Genetic mutations in FBN1 can lead to various connective tissue disorders, affecting tissue strength and flexibility.

What is the impact of altered FBN1 activity on cardiovascular health?

Altered FBN1 activity is associated with cardiovascular conditions due to its role in maintaining blood vessel structure.

What role does FBN1 play in connective tissue development?

FBN1 plays a critical role in the development of connective tissues, including tendons, ligaments, and blood vessels.

What is the primary role of FBN1 in extracellular matrix formation?

FBN1, or Fibrillin-1, is essential for the formation of the extracellular matrix, providing structural support to tissues.

How does FBN1 interact with other extracellular matrix proteins?

FBN1 interacts with other extracellular matrix proteins, such as elastin, in building and maintaining tissue architecture.

How does FBN1 contribute to tissue elasticity and structural integrity?

It contributes to tissue elasticity and integrity by forming microfibrils that reinforce the matrix.