Recombinant Human FGFR4 Protein, His-tagged

• Cat.No.: FGFR4-035H
• Product Overview: Recombinant Human FGFR4 Protein with His tag was expressed in E. coli.

Specification

• Description: Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through cell surface receptor tyrosine kinases. There are four members of the FGF receptor family: FGFR1 (flg), FGFR2 (bek, KGFR), FGFR3, and FGFR4. Each receptor contains an extracellular ligand binding domain, a transmembrane domain, and a cytoplasmic kinase domain. Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues. Seven tyrosine residues in the cytoplasmic tail of FGFR1 can be phosphorylated: Tyr463, 583, 585, 653, 654, 730, and 766. Tyr653 and Tyr654 are important for catalytic activity of activated FGFR and are essential for signaling. The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCγ.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: ~43 kDa
• AA Sequence: DPLEASEEVELEPCLAPSLEQQEQE LTVALGQPVRLCCGRAERGGHWYKE GSRLAPAGRVRGWRGRLEIASFLPE DAGRYLCLARGSMIVLQNLTLITGD SLTSSNDDEDPKSHRDPSNRHSYPQ QAPYWTHPQRMEKKLHAVPAGNTVK FRCPAAGNPTPTIRWLKDGQAFHGE NRIGGIRLRHQHWSLVMESVVPSDR GTYTCLVENAVGSIRYNYLLDVLER SPHRPILQAGLPANTTAVVGSDVEL LCKVYSDAQPHIQWLKHIVINGSSF GADGFPYVQVLKTADINSSEVEVLY LRNVSAEDAGEYTCLAGNSIGLSYQ SAWLTVLPEEDPTWTAAAPEARYTD
• Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).
• Notes: For research use only, not for use in diagnostic procedure.
• Storage: Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles.
• Storage Buffer: PBS, 4M Urea, pH7.4

Gene Information

• Gene Name: FGFR4 fibroblast growth factor receptor 4 [ Homo sapiens (human) ]
• Official Symbol: FGFR4
• Synonyms: FGFR4; fibroblast growth factor receptor 4; CD334; JTK2; FGFR-4; tyrosylprotein kinase; protein-tyrosine kinase; hydroxyaryl-protein kinase; tyrosine kinase related to fibroblast growth factor receptor; TKF; MGC20292
• Gene ID: 2264
• mRNA Refseq: NM_002011
• Protein Refseq: NP_002002
• MIM: 134935
• UniProt ID: P22455