Recombinant Human FUS Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: FUS-5669H
• Product Overview: FUS MS Standard C13 and N15-labeled recombinant protein (NP_004951) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 53.4 kDa
• AA Sequence: MASNDYTQQATQSYGAYPTQPGQGY SQQSSQPYGQQSYSGYSQSTDTSGY GQSSYSSYGQSQNTGYGTQSTPQGY GSTGGYGSSQSSQSSYGQQSSYPGY GQQPAPSSTSGSYGSSSQSSSYGQP QSGSYSQQPSYGGQQQSYGQQQSYN PPQGYGQQNQYNSSSGGGGGGGGGG NYGQDQSSMSSGGGSGGGYGNQDQS GGGGSGGYGQQDRGGRGRGGSGGGG GGGGGGYNRSSGGYEPRGRGGGRGG RGGMGGSDRGGFNKFGGPRDQGSRH DSEQDNSDNNTIFVQGLGENVTIES VADYFKQIGIIKTNKKTGQPMINLY TDRETGKLKGEATVSFDDPPSAKAA IDWFDGKEFSGNPIKVSFATRRADF NRGGGNGRGGRGRGGPMGRGGYGGG GSGGGGRGGFPSGGGGGGGQQRAGD WKCPNPTCENMNFSWRNECNQCKAP KPDGPGGGPGGSHMGGNYGDDRRGG RGGYDRGGYRGRGGDRGGFRGGRGG GDRGGFGPGKMDSRGEHRQDRRERP YTRTRPLEQKLISEEDLAANDILDY KDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: FUS fused in sarcoma [ Homo sapiens (human) ]
• Official Symbol: FUS
• Synonyms: FUS; fused in sarcoma; ALS6, amyotrophic lateral sclerosis 6, fusion (involved in t(12;16) in malignant liposarcoma), fusion, derived from t(12;16) malignant liposarcoma; RNA-binding protein FUS; FUS1; heterogeneous nuclear ribonucleoprotein P2; hnRNP P2; TLS; translocated in liposarcoma; oncogene FUS; oncogene TLS; fus-like protein; 75 kDa DNA-pairing protein; fusion gene in myxoid liposarcoma; translocated in liposarcoma protein; ALS6; POMP75; HNRNPP2
• Gene ID: 2521
• mRNA Refseq: NM_004960
• Protein Refseq: NP_004951
• MIM: 137070
• UniProt ID: P35637