Recombinant Human GP1BA Protein, His-tagged
Cat.No. : | GP1BA-16H |
Product Overview : | Recombinant Human GP1BA(Met1-Gly519) fused with His tag at the C-terminus was produced in HEK293. |
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Description : | Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Predicted N Terminal : | His 17 |
Form : | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements. |
Molecular Mass : | The recombinant human GP1BA consists of 514 amino acids and predicts a molecular mass of 56.7 kDa. |
Protein length : | Met1-Gly519 |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method |
Purity : | > 90 % as determined by SDS-PAGE. |
Stability : | Samples are stable for up to twelve months from date of receipt at -70 centigrade |
Storage : | Store it under sterile conditions at -20 centigrade to -80 centigrade upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles. |
Gene Name : | GP1BA glycoprotein Ib (platelet), alpha polypeptide [ Homo sapiens ] |
Official Symbol : | GP1BA |
Synonyms : | GP1BA; glycoprotein Ib (platelet), alpha polypeptide; GP1B; platelet glycoprotein Ib alpha chain; CD42b; GP-Ib alpha; antigen CD42b-alpha; platelet membrane glycoprotein 1b-alpha subunit; BSS; VWDP; CD42B; GPIbA; BDPLT1; BDPLT3; DBPLT3; CD42b-alpha; MGC34595; |
Gene ID : | 2811 |
mRNA Refseq : | NM_000173 |
Protein Refseq : | NP_000164 |
MIM : | 606672 |
UniProt ID : | P07359 |
Products Types
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GP1BA-683H | Recombinant Human GP1BA Protein, His-tagged | +Inquiry |
GP1BA-5130H | Recombinant Human GP1BA Protein, GST-tagged | +Inquiry |
GP1BA-531H | Recombinant Human GP1BA Protein (17-505 aa), His-tagged | +Inquiry |
◆ Lysates | ||
GP1BA-5823HCL | Recombinant Human GP1BA 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionGlycoprotein Ib platelet subunit alpha (GP1BA) plays a crucial role in platelet physiology and hemostasis, specifically in platelet adhesion.
Dysregulation or abnormal expression of GP1BA is associated with conditions such as Bernard-Soulier syndrome and other platelet disorders.
GP1BA contributes to platelet adhesion by interacting with von Willebrand factor (vWF), facilitating platelet plug formation at vascular injury sites.
Interactions or binding partners of GP1BA include vWF and other components of the platelet glycoprotein Ib-IX-V complex, influencing platelet function.
GP1BA participates in the regulation of blood clotting and coagulation cascades by initiating platelet activation and aggregation.
GP1BA is predominantly localized on the surface of platelets, especially within the platelet membrane.
There are potential therapeutic implications related to GP1BA in diseases involving platelet disorders, making it a target for drug development.
Customer Reviews (3)
Write a reviewIts compatibility with collaborative platforms and open-source tools facilitated sharing and reproducibility of our experiments.
The product's support in the form of educational resources positively impacted the learning curve for our researchers.
The product's track record of being featured in influential publications positively influenced our decision to use it.
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