Recombinant Human HAVCR2 protein, Fc-tagged
Cat.No. : | HAVCR2-876H |
Product Overview : | Recombinant Human HAVCR2 protein (Ser22-Arg200), fused to human IgG1 Fc tag at C-terminus, was expressed in human 293 cells (HEK293). |
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Description : | Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis. |
Source : | HEK293 |
Species : | Human |
Tag : | human IgG1 Fc |
Form : | Lyophilized from 0.22 um filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 46.5 kDa. The protein migrates as 55-67 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | 179 |
Endotoxin : | Less than 1.0 EU per ug by the LAL method. |
Purity : | >85% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 centigrade to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | HAVCR2 |
Official Symbol : | HAVCR2 |
Synonyms : | HAVCR2; hepatitis A virus cellular receptor 2; FLJ14428; Tim 3; TIM3; TIMD3; kidney injury molecule-3; T-cell membrane protein 3; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; T-cell immunoglobulin and mucin domain-containing protein 3; KIM-3; Tim-3; TIMD-3; HAVcr-2 |
Gene ID : | 84868 |
mRNA Refseq : | NM_032782 |
Protein Refseq : | NP_116171 |
MIM : | 606652 |
UniProt ID : | Q8TDQ0 |
Products Types
◆ Recombinant Protein | ||
HAVCR2-111H | Recombinant Human HAVCR2 Protein (ECD), His-tagged(C-ter) | +Inquiry |
HAVCR2-739M | Recombinant Mouse HAVCR2 Protein, Fc-tagged | +Inquiry |
Havcr2-138M | Recombinant Mouse Havcr2 Protein, His (Fc)-Avi-tagged | +Inquiry |
HAVCR2-736H | Recombinant Human HAVCR2 Protein, Strep-tagged | +Inquiry |
HAVCR2-149H | Recombinant Human HAVCR2 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
HAVCR2-995MCL | Recombinant Mouse HAVCR2 cell lysate | +Inquiry |
HAVCR2-001CCL | Recombinant Cynomolgus HAVCR2 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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