Recombinant Human HDAC6 Protein, GST-tagged

• Cat.No.: HDAC6-41H
• Product Overview: Recombinant human HDAC6 protein with a N-terminal GST-tag was expressed in Sf21 cells.

Specification

• Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.
• Source: Insect cells
• Species: Human
• Tag: GST
• Molecular Mass: 159 kDa
• Purity: ≥65% estimated by SDS-PAGE
• Unit Definition: One unit is the amount of enzyme required to release 1 pmol of acetate per minute at 37 centigrade in 25 mM Tris/HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, 0.1 mg/mL BSA, and 20 μM fluorogenic HDAC substrate 3.
• Stability: ≥ 6 months
• Storage: Store it at -80 centigrade
• Storage Buffer: 40 mM Tris-HCl pH8.0, 110mM sodium chloride, with 2.2 mM potassium chloride, 0.04% Tween20, 3mM DTT, and 20% glycerol

Gene Information

• Gene Name: HDAC6 histone deacetylase 6 [ Homo sapiens (human) ]
• Official Symbol: HDAC6
• Synonyms: HDAC6; histone deacetylase 6; HD6; JM21; CPBHM; PPP1R90; histone deacetylase 6; protein phosphatase 1, regulatory subunit 90; tubulin-lysine deacetylase HDAC6
• Gene ID: 10013
• mRNA Refseq: NM_001321226
• Protein Refseq: NP_001308155
• MIM: 300272
• UniProt ID: Q9UBN7