Recombinant Human HTR1B Protein (N32-I239, L138W, A306-S390 end), Flag, His tagged

• Cat.No.: HTR1B-0500H
• Product Overview: Recombinant Human Flag-10His-TEV-5HT1B(N32-I239) (L138W)-BRIL-5HT1B(A306-S390 end) Protein was expressed in Insect cell.

Specification

• Description: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
• Source: Insect cell
• Species: Human
• Tag: Flag,His
• Form: Liquid
• Protein Length: N32-I239, L138W, A306-S390 end
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Formulation:
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled [ Homo sapiens (human) ]
• Official Symbol: HTR1B
• Synonyms: HTR1B; 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled; 5 hydroxytryptamine (serotonin) receptor 1B; 5-hydroxytryptamine receptor 1B; 5 HT1B; 5 HT1DB; HTR1D2; S12; 5-HT-1B; 5-HT-1D-beta; serotonin receptor 1B; serotonin 1D beta receptor; 5-HT1B; HTR1DB; 5-HT1DB
• Gene ID: 3351
• mRNA Refseq: NM_000863
• Protein Refseq: NP_000854
• MIM: 182131
• UniProt ID: P28222