| Description : |
This protein is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn s disease and leprosy, which is thought to contribute to the inflammatory response and host defense. |
| Source : |
Yeast |
| Species : |
Human |
| Tag : |
His |
| Form : |
Tris-based buffer,50% glycerol |
| Molecular Mass : |
69.7kD |
| Protein length : |
24-622aa |
| AA Sequence : |
KIDACKRGDVTVKPSHVILLGSTVN ITCSLKPRQGCFHYSRRNKLILYKF DRRINFHHGHSLNSQVTGLPLGTTL FVCKLACINSDEIQICGAEIFVGVA PEQPQNLSCIQKGEQGTVACTWERG RDTHLYTEYTLQLSGPKNLTWQKQC KDIYCDYLDFGINLTPESPESNFTA KVTAVNSLGSSSSLPSTFTFLDIVR PLPPWDIRIKFQKASVSRCTLYWRD EGLVLLNRLRYRPSNSRLWNMVNVT KAKGRHDLLDLKPFTEYEFQISSKL HLYKGSWSDWSESLRAQTPEEEPTG MLDVWYMKRHIDYSRQQISLFWKNL SVSEARGKILHYQVTLQELTGGKAM TQNITGHTSWTTVIPRTGNWAVAVS AANSKGSSLPTRINIMNLCEAGLLA PRQVSANSEGMDNILVTWQPPRKDP SAVQEYVVEWRELHPGGDTQVPLNW LRSRPYNVSALISENIKSYICYEIR VYALSGDQGGCSSILGNSKHKAPLS GPHINAITEEKGSILISWNSIPVQE QMGCLLHYRIYWKERDSNSQPQLCE IPYRVSQNSHPINSLQPRVTYVLWM TALTAAGESSHGNEREFCLQGKAN |
| Purity : |
>90% ( SDS-PAGE ) |
| Notes : |
Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week. |
| Storage : |
Store at -20 centigrade, for extended storage, conserve at -20 centigrade or -80 centigrade. |
