| Description : |
Interleukin 13 (IL13) is also known as ALRH, BHR1and P600, is a single-chain glycosylated polypeptide, and is a cytokine critical in regulating inflammatory and immune responses. IL13 is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains. The functions of IL-13 overlap considerably with those of IL-4, especially with regard to changes induced on hematopoietic cells, but these effects are probably less important given the more potent role of IL-4. IL-13 induces matrix metalloproteinases (MMPs) as part of a mechanism that protects against excessive allergic inflammation that predisposes to asphyxiation. IL-13 induces many features of allergic lung disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, which all contribute to airway obstruction. |
| Source : |
Mammalian cells |
| Species : |
Human |
| Tag : |
C-Fc |
| Form : |
Lyophilized powder/frozen liquid |
| Molecular Mass : |
37.43 kDa |
| Protein Length : |
Gly35-Asn146 |
| Endotoxin : |
< 1.0 EU/μg of the protein as determined by the LAL method. |
| Purity : |
>90% as determined by SDS-PAGE. |
| Notes : |
For research use only. |
| Storage : |
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt. |
| Storage Buffer : |
Supplied as solution form in PBS or lyophilized from PBS. |
| Reconstitution : |
Reconstitute in sterile water for a stock solution. |
| Shipping : |
They are shipped out with dry ice/blue ice unless customers require otherwise. |
