Recombinant Human IL13RA2

• Cat.No.: IL13RA2-28498TH
• Product Overview: Recombinant fragment of Human IL13 receptor alpha 2 with N terminal proprietary tag, 36.63kDa.

Specification

• Description: The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13.
• Protein length: 100 amino acids
• Molecular Weight: 36.630kDa inclusive of tags
• Source: Wheat germ
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: DTEIKVNPPQDFEIVDPGYLGYLYL QWQPPLSLDHFKECTVEYELKYRNI GSETWKTIITKNLHYKDGFDLNKGI EAKIHTLLPWQCTNGSEVQSSWAET
• Sequence Similarities: Belongs to the type I cytokine receptor family. Type 5 subfamily.Contains 1 fibronectin type-III domain.

Gene Information

• Gene Name: IL13RA2 interleukin 13 receptor, alpha 2 [ Homo sapiens ]
• Official Symbol: IL13RA2
• Synonyms: IL13RA2; interleukin 13 receptor, alpha 2; interleukin-13 receptor subunit alpha-2; cancer/testis antigen 19; CD213a2; CT19; IL 13R; IL13BP
• Gene ID: 3598
• mRNA Refseq: NM_000640
• Protein Refseq: NP_000631
• MIM: 300130
• Uniprot ID: Q14627
• Chromosome Location: Xq13.1-q28
• Pathway: IL4-mediated signaling events, organism-specific biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem
• Function: cytokine receptor activity; receptor activity; signal transducer activity

Reviews

07/14/2019

Reliable in co-immunoprecipitation.

09/24/2018

High specificity.

01/05/2017

Effective in asthma models.

Q&As

What experimental methods determine IL13RA2's role in cancer metastasis?

Methods unveil IL13RA2's role in cancer metastasis.

How does proximity ligation assay reveal IL13RA2 interactions with other proteins?

Proximity ligation assay exposes IL13RA2 interactions with proteins.

Can you elaborate on the use of immunohistochemistry in studying IL13RA2 expression in tissues?

Immunohistochemistry maps IL13RA2 expression in tissues.

How do structural studies such as X-ray crystallography inform IL13RA2's ligand binding mechanism?

Structural studies like X-ray crystallography illuminate IL13RA2's ligand binding mechanism.

What are the advantages of using siRNA libraries to explore IL13RA2 functions?

siRNA libraries probe diverse IL13RA2 functions advantageously.

Could you describe how CRISPR screening identifies regulators of IL13RA2 expression?

CRISPR screening identifies regulators of IL13RA2 expression.

What techniques investigate IL13RA2 dimerization in cellular contexts?

Techniques reveal IL13RA2 dimerization in cellular settings.

Could you explain how mass spectrometry identifies IL13RA2 post-translational modifications?

Mass spectrometry detects IL13RA2 post-translational modifications.

How does surface plasmon resonance (SPR) analyze IL13RA2 binding affinities?

SPR quantifies IL13RA2 binding affinities with precision.

How do reporter gene assays assess IL13RA2-mediated signaling pathways?

Reporter gene assays illuminate IL13RA2-mediated signaling.