Recombinant Human IL13RA2 protein, hFc-tagged

• Cat.No.: IL13RA2-732H
• Product Overview: Recombinant Human IL-13 R alpha 2 Protein is expressed from mammalian with a hFc Tag at the C-terminal. It contains Asp27-Leu342.

Specification

• Description: Two type 1 membrane proteins belonging to the hemopoietin receptor family have been cloned and shown to bind IL-13 with differing affinities. The lower affinity IL-13 binding protein, previously designated IL-13 R alpha, IL-13 R alpha ' or NR4, is now referred to as IL-13 R alpha 1. The high-affinity IL-13 binding protein, previously also designated IL-13 R or IL-13 R alpha ', is now referred to as IL-13 R alpha 2.
• Source: HEK293
• Species: Human
• Tag: hFc
• Form: Supplied as 0. 22um filtered solution in PBS (pH 7. 4).
• Molecular Mass: The protein has a predicted MW of 63. 7 KDa. Due to glycosylation, the protein migrates to 70-80 KDa based on Bis-Tris PAGE result.
• Protein length: It contains Asp27-Leu342.
• Endotoxin: Less than 0. 05 EU per ug by the LAL method.
• Purity: > 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: IL13RA2 interleukin 13 receptor, alpha 2 [ Homo sapiens ]
• Official Symbol: IL13RA2
• Synonyms: CD213a2 antigen; CD213a2; CT19; IL-13 R alpha 2; IL-13 receptor subunit alpha-2;cancer/testis antigen 19; IL13BP; IL13R alpha 2; IL-13R subunit alpha-2; IL13R; IL-13R; IL13RA2; IL-13Ra2; IL-13R-alpha-2; interleukin 13 binding protein; interleukin 13 receptor alpha 2 chain; interleukin 13 receptor, alpha 2; interleukin-13 receptor subunit alpha-2; Interleukin-13-binding protein
• Gene ID: 3598
• mRNA Refseq: NM_000640
• Protein Refseq: NP_000631
• MIM: 300130
• UniProt ID: Q14627

Reviews

07/14/2019

Reliable in co-immunoprecipitation.

09/24/2018

High specificity.

01/05/2017

Effective in asthma models.

Q&As

What experimental methods determine IL13RA2's role in cancer metastasis?

Methods unveil IL13RA2's role in cancer metastasis.

How does proximity ligation assay reveal IL13RA2 interactions with other proteins?

Proximity ligation assay exposes IL13RA2 interactions with proteins.

Can you elaborate on the use of immunohistochemistry in studying IL13RA2 expression in tissues?

Immunohistochemistry maps IL13RA2 expression in tissues.

How do structural studies such as X-ray crystallography inform IL13RA2's ligand binding mechanism?

Structural studies like X-ray crystallography illuminate IL13RA2's ligand binding mechanism.

What are the advantages of using siRNA libraries to explore IL13RA2 functions?

siRNA libraries probe diverse IL13RA2 functions advantageously.

Could you describe how CRISPR screening identifies regulators of IL13RA2 expression?

CRISPR screening identifies regulators of IL13RA2 expression.

What techniques investigate IL13RA2 dimerization in cellular contexts?

Techniques reveal IL13RA2 dimerization in cellular settings.

Could you explain how mass spectrometry identifies IL13RA2 post-translational modifications?

Mass spectrometry detects IL13RA2 post-translational modifications.

How does surface plasmon resonance (SPR) analyze IL13RA2 binding affinities?

SPR quantifies IL13RA2 binding affinities with precision.

How do reporter gene assays assess IL13RA2-mediated signaling pathways?

Reporter gene assays illuminate IL13RA2-mediated signaling.