Recombinant Human IL1R2 protein, Fc-tagged
Cat.No. : | IL1R2-773H |
Product Overview : | Recombinant Human IL1R2 (Phe14-Glu343) protein was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293). |
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Description : | Interleukin-1 receptor type 2 (IL1R2) is also known as CD121 antigen-like family member B (CDw121b), IL-1 type II receptor, Interleukin-1 receptor type II, belongs to the interleukin-1 receptor family. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R2 is non-signaling receptor for IL1A, IL1B and IL1RN, reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. |
Source : | HEK293 |
Species : | Human |
Tag : | human IgG1 Fc |
Predicted N Terminal : | Phe14 |
Form : | Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 64 kDa. The protein migrates as 68-74 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | Phe14-Glu343 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | IL1R2 |
Official Symbol : | IL1R2 |
Synonyms : | IL1R2; interleukin 1 receptor, type II; IL1RB; interleukin-1 receptor type 2; CD121b; CDw121b; IL-1R-2; IL-1RT2; IL-1RT-2; IL-1R-beta; antigen CDw121b; IL-1 type II receptor; interleukin-1 receptor beta; interleukin-1 receptor type II; CD121 antigen-like family member B; type II interleukin-1 receptor, beta; MGC47725 |
Gene ID : | 7850 |
mRNA Refseq : | NM_004633 |
Protein Refseq : | NP_004624 |
MIM : | 147811 |
UniProt ID : | P27930 |
Products Types
◆ Recombinant Protein | ||
IL1R2-307H | Recombinant Human IL1R2 Protein, Fc-tagged | +Inquiry |
IL1R2-1821H | Recombinant Human IL1R2 Protein, MYC/DDK-tagged | +Inquiry |
IL1R2-1669H | Recombinant Human IL1R2 Protein, His&GST-tagged | +Inquiry |
IL1R2-165H | Recombinant Human IL1R2 Protein (ECD), Fc-His-tagged(C-ter) | +Inquiry |
Il1r2-1242M | Recombinant Mouse Il1r2 Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
IL1R2-1227CCL | Recombinant Cynomolgus IL1R2 cell lysate | +Inquiry |
IL1R2-1376MCL | Recombinant Mouse IL1R2 cell lysate | +Inquiry |
IL1R2-1302RCL | Recombinant Rat IL1R2 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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