Recombinant Human IL1RN therapeutic protein
Cat.No. : | IL1RN-P038H |
Product Overview : | The therapeutic protein is a recombinant, nonglycosylated human interleukin-1 receptor antagonist (IL-1Ra). The difference between the protein and the native human IL-1Ra is that the protein has an extra methionine residue at the amino terminus. It is manufactured by using the E. coli expression system. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. The expression product is the active ingredient of Kineret. |
Source : | E. coli |
Species : | Human |
Molecular Mass : | 17.3 kDa |
Protein length : | 153 aa |
AA Sequence : | MRPSGRKSSKMQAFRIWDVNQKTFY LRNNQLVAGYLQGPNVNLEEKIDVV PIEPHALFLGIHGGKMCLSCV KSGDETRLQLEAVNITDLSENRKQD KRFAFIRSDSGPTTSFESAACPGWF LCTAMEADQPVSLTNMPDEGV MVTKFYFQEDE |
Endotoxin : | < 0.1 EU per μg of the protein |
Purity : | >95% |
Storage : | Can be stored at +4 centigrade short term (1-2weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoidrepeated freezing and thawing cycles. |
Gene Name : | IL1RN interleukin 1 receptor antagonist [ Homo sapiens ] |
Official Symbol : | IL1RN |
Synonyms : | IL1RN; interleukin 1 receptor antagonist; interleukin-1 receptor antagonist protein; ICIL 1RA; IL 1RN; IL1F3; IL1RA; interleukin 1 receptor antagonist protein; intracellular interleukin 1 receptor antagonist; IRAP; MGC10430; IL1 inhibitor; IL1RN (IL1F3); type II interleukin-1 receptor antagonist; intracellular IL-1 receptor antagonist type II; intracellular interleukin-1 receptor antagonist (icIL-1ra); DIRA; MVCD4; IL-1RN; IL-1ra; IL-1ra3; ICIL-1RA; |
Gene ID : | 3557 |
mRNA Refseq : | NM_000577 |
Protein Refseq : | NP_000568 |
MIM : | 147679 |
UniProt ID : | P18510 |
Chromosome Location : | 2q14.2 |
Pathway : | Cytokine Signaling in Immune system, organism-specific biosystem; IL-1 Signaling Pathway, organism-specific biosystem; IL1-mediated signaling events, organism-specific biosystem; Immune System, organism-specific biosystem; Interleukin-1 signaling, organism-specific biosystem; Signaling by Interleukins, organism-specific biosystem; |
Function : | interleukin-1 Type I receptor antagonist activity; interleukin-1 Type II receptor antagonist activity; interleukin-1 receptor antagonist activity; interleukin-1 receptor antagonist activity; interleukin-1 receptor binding; interleukin-1, Type I receptor binding; interleukin-1, Type II receptor binding; |
Products Types
◆ Recombinant Protein | ||
IL1RN-103I | Active Recombinant Human IL1RN Protein (153 aa) | +Inquiry |
IL1RN-164H | Active Recombinant Human IL1RN Protein (Arg26-Glu177), C-His tagged, Animal-free, Carrier-free | +Inquiry |
Il1rn-2299R | Recombinant Rat Il1rn Protein, His-tagged | +Inquiry |
IL1RN-167H | Recombinant Active Human IL1RN Protein, His-tagged(C-ter) | +Inquiry |
Il1rn-168M | Recombinant Active Mouse IL1RN Protein, His-tagged(C-ter) | +Inquiry |
◆ Lysates | ||
IL1RN-2912HCL | Recombinant Human IL1RN cell lysate | +Inquiry |
IL1RN-1375RCL | Recombinant Rat IL1RN cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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