Recombinant Human IL31 protein, His-tagged

• Cat.No.: IL31-311H
• Product Overview: Recombinant Human IL31 protein(NP_001014358.1) (Met1-Thr164) was expressed in HEK293 with a polyhistidine tag at the C-terminus.

Specification

• Source: HEK293
• Species: Human
• Tag: C-His
• Protein length: Met1-Thr164
• Form: Lyophilized from sterile PBS, pH 7.4.
• Bio-activity: Measured by its ability to induce STAT3 activation in U‑87 cells. The ED50 for this effect is 11-45 ng/mL.
• Molecular Mass: The recombinant human IL31 consists of 152 amino acids and predicts a molecular mass of 17.3 KDa. It migrates as an approximately 31.8 KDa band in SDS-PAGE under reducing conditions due to glycosylation.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: IL31 interleukin 31 [ Homo sapiens ]
• Official Symbol: IL31
• Synonyms: IL31; interleukin 31; interleukin-31; IL 31; IL-31
• Gene ID: 386653
• mRNA Refseq: NM_001014336
• Protein Refseq: NP_001014358
• MIM: 609509
• UniProt ID: Q6EBC2

Reviews

04/22/2022

IL31 product has strict quality control and complies with relevant industry standards.

09/26/2021

It performs well in biological activity tests.

09/13/2020

This protein has high yield and good economic benefits.

Q&As

What are the advantages of IL31 compared with other therapeutic methods?

The IL31 may have specificity for specific diseases, with relatively few side effects being a big advantage.

What is the action mechanism of IL31?

IL31 activates downstream signaling pathways by binding to receptors and participates in inflammatory response and immune regulation.

In what research areas is this protein used in the laboratory?

It has a wide range of applications in immune inflammation, dermatology and other research fields.

How is the clinical research progress of IL31?

Clinical studies of IL31 are ongoing, but there is no clear therapeutic effect and effectiveness assessment at this time.

Are there some challenges in the study of IL31?

IL31 research still faces many challenges, including side effect evaluation, efficacy verification and other issues, and further efforts are needed.

How to determine the optimal dose of IL31 for treatment?

Optimal dose may be related to individual differences, disease type and other factors, and the appropriate dose should be determined under the guidance of a doctor when using IL31.