Recombinant Human IL4R Protein, C-His-tagged
Cat.No. : | IL4R-068H |
Product Overview : | Recombinant Human IL4R Protein with C-His tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | The IL-2 receptor is a multicomponent complex consisting of three subunits, α, β and γ, each of which is required for high affinity binding of IL-2. The α chain functions primarily in binding IL-2, whereas the β and γ chains contribute to IL-2 binding and are essential to IL-2-induced activation of signaling pathways leading to T cell growth. Both IL-4R and IL-7R were initially described as single chain, high-affinity ligand-binding cytokine receptors. However, it is now well established that the IL-2Rγ chain functions as a second subunit of the high affinity IL-4R and IL-7R receptors. Consequently, the originally described subunits of these latter receptors are now referred to as IL-4Rα and IL-7Rα, respectively, while the common subunit is referred to as γc. Although the common γ chain enhances ligand binding in these three cytokine receptors, it has no capacity to bind these ligands on its own. There is evidence that the γc chain is also a subunit of IL-13R. |
Source : | E. coli |
Species : | Human |
Tag : | C-His |
Molecular Mass : | ~23 kDa |
AA Sequence : | KVLQEPTCVSDYMSISTCEWKMNGP TNCSTELRLLYQLVFLLSEAHTCIP ENNGGAGCVCHLLMDDVVSADNYTL DLWAGQQLLWKGSFKPSEHVKPRAP GNLTVHTNVSDTLLLTWSNPYPPDN YLYNHLTYAVNIWSENDPADFRIYN VTYLEPSLRIAASTLKSGISYRARV RAWAQCYNTTWSEWSPSTKWHNSYR EPFEQH |
Purity : | Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). |
Notes : | For research use only, not for use in diagnostic procedure. |
Storage : | Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. |
Concentration : | ≥0.5 mg/mL |
Storage Buffer : | PBS, 4M Urea, pH7.4 |
Gene Name : | IL4R interleukin 4 receptor [ Homo sapiens (human) ] |
Official Symbol : | IL4R |
Synonyms : | IL4R; interleukin 4 receptor; interleukin-4 receptor subunit alpha; CD124; IL-4 receptor subunit alpha; interleukin-4 receptor alpha chain; IL4RA; IL-4RA; |
Gene ID : | 3566 |
mRNA Refseq : | NM_000418 |
Protein Refseq : | NP_000409 |
MIM : | 147781 |
UniProt ID : | P24394 |
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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