Recombinant Human IL5 protein(Met1-Ser134), His-tagged

• Cat.No.: IL5-502H
• Product Overview: Recombinant Human IL5 (NP_000870.1) (Met1-Ser134) was expressed in HEK293 with a polyhistidine tag at the C-terminus.

Specification

• Source: HEK293
• Species: Human
• Tag: C-His
• Protein length: Met1-Ser134
• Form: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Bio-activity: Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is typically 0.2-1.2 ng/mL.
• Molecular Mass: The recombinant human IL5 consists of 126 amino acids and predicts a molecular mass of 14.6 kDa.
• Endotoxin: < 1.0 EU per μg protein as determined by the LAL method.
• Purity: > 95 % as determined by SDS-PAGE.
• Storage: Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: IL5 interleukin 5 (colony-stimulating factor, eosinophil) [ Homo sapiens ]
• Official Symbol: IL5
• Synonyms: IL5; interleukin 5 (colony-stimulating factor, eosinophil); interleukin-5; B cell differentiation factor I; EDF; eosinophil differentiation factor; IL 5; interleukin 5; T cell replacing factor; TRF; T-cell replacing factor; B-cell differentiation factor I; IL-5
• Gene ID: 3567
• mRNA Refseq: NM_000879
• Protein Refseq: NP_000870
• MIM: 147850
• UniProt ID: P05113

Reviews

07/26/2022

High efficacy and safety in clinical treatment.

06/22/2022

There are no structural or functional defects.

01/31/2019

The stability and activity are maintained well during long-term storage.

Q&As

Which effect of IL5 in the treatment of tuberous sclerosis?

Inhibit the creatinine kinase level in the blood of patients with tuberous sclerosis, reduce the inflammatory response, and improve the quality of life of patients.

Does there have any effect of IL5 in the treatment of allergic rhinitis?

IL5 can reduce the number of eosinophils in the nasal mucosa of patients with allergic rhinitis, reducing the symptoms of allergic reactions, such as sneezing, runny nose and nasal congestion.

What is the main function of IL5?

Stimulate the proliferation and differentiation of white blood cells, promote the function of the immune system, and is used to treat diseases such as asthma, allergic rhinitis, nodular sclerosis and some malignant tumors.

Does IL5 have side effects?

Cause mild side effects such as headache, nausea, vomiting, and serious side effects such as allergic reactions if the dose is too large or allergic.

Can IL5 be administered orally?

IL5 cannot be administered orally, only by injection or intravenous drip.

What is the effect of IL5 in the treatment of asthma?

IL5 can reduce the number of eosinophils in the lungs of asthma patients, reduce the frequency and severity of asthma attacks, and improve the quality of life of patients.