| Description : |
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). |
| Species : |
Human |
| Form : |
Lyophilized |
| Protein Length : |
212 |
| AA Sequence : |
MNSFSTSAFGPVAFSLGLLLVLPAA FPAPVPPGEDSKDVAAPHRQPLTSS ERIDKQIRYILDGISALRKETCNKS NMCESSKEALAENNLNLPKMAEKDG CFQSGFNEETCLVKIITGLLEFEVY LEYLQNRFESSEEQARAVQMSTKVL IQFLQKKAKNLDAITTPDPTTNASL LTKLQAQNQWLQDMTTHLILRSFKE FLQSSLRALRQM |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
