Recombinant Human Interleukin 1 Receptor-Like 1, His-tagged
Cat.No. : | IL1RL1-396H |
Product Overview : | IL1RL1 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 310 amino acids fragment (19-328) corresponding to the soluble IL1RL1 coding sequence, having a molecular weight of 36kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The IL1RL1 is purified by proprietary chromatographic techniques. |
- Specification
- Gene Information
- Related Products
- Download
Cat. No. : | IL1RL1-396H |
Description : | The IL1RL1 gene is a member of the IL-1 receptor family, encoding a transmembrane protein with a structure similar to IL-1R1. IL1RL1 is a receptor for interleukin-33, its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. IL1RL1 may possibly be involved in helper T-cell function. IL1RL1 is highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. A soluble form of the IL1RL1 is produced from the same gene by alternative splicing and was shown to be expressed in several cell types including fibroblasts and mast cells. Soluble IL1RL1 also acts as a negative regulator of Th2 cytokine production and high levels have been reported in several disease states and conditions including asthma, sepsis and myocardial infarction. Analysis of the similar gene in mouse suggested that the IL1RL1 receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. |
Source : | Human |
Host : | Escherichia Coli. |
Form : | IL1RL1 protein is supplied in 1xPBS, 50% glycerol. |
Purity : | Greater than 95.0% as determined by SDS-PAGE. |
Physical Appearance : | Sterile Filtered clear solution. |
Storage : | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles. |
Gene Name : | IL1RL1 interleukin 1 receptor-like 1 [ Homo sapiens ] |
Official Symbol : | IL1RL1 |
Synonyms : | IL1RL1; interleukin 1 receptor-like 1; T1; ST2; DER4; ST2L; ST2V; FIT-1; MGC32623; growth stimulation-expressed; interleukin 1 receptor-related protein; homolog of mouse growth stimulation-expressed; nterleukin-1 receptor-like 1; Protein ST2; OTTHUMP00000161342 |
Gene ID : | 9173 |
mRNA Refseq : | NM_003856 |
Protein Refseq : | NP_003847 |
MIM : | 601203 |
UniProt ID : | Q01638 |
Chromosome Location : | 2q12 |
Function : | interleukin-1 receptor activity; interleukin-33 receptor activity; protein binding; receptor signaling protein activity |
Products Types
◆ Recombinant Protein | ||
IL1RL1-317H | Recombinant Human IL1RL1 Protein, His-tagged | +Inquiry |
IL1RL1-2690R | Recombinant Rat IL1RL1 Protein, His (Fc)-Avi-tagged | +Inquiry |
IL1RL1-195H | Recombinant Human IL1RL1 Protein, His (Fc)-Avi-tagged | +Inquiry |
IL1RL1-775H | Recombinant Human IL1RL1 protein(Met1-Phe328) | +Inquiry |
IL1RL1-318H | Recombinant Human IL1RL1 Protein, Fc-tagged | +Inquiry |
◆ Lysates | ||
IL1RL1-001MCL | Recombinant Mouse IL1RL1 cell lysate | +Inquiry |
IL1RL1-2481HCL | Recombinant Human IL1RL1 cell lysate | +Inquiry |
IL1RL1-1883HCL | Recombinant Human IL1RL1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (10)
Ask a questionIL1RL1 has multiple splice variants that differ in signaling capabilities.
IL1RL1 suppresses allergic responses by inhibiting mast cell activation.
IL1RL1 is implicated in rheumatoid arthritis.
IL1RL1 increases the production of IL-4 and IL-13.
IL1RL1 is primarily membrane-bound.
IL1RL1 promotes Th2 cell differentiation.
IL1RL1 binds to IL-33 and IL-36 to initiate signaling.
IL1RL1 expression is altered in lung and breast cancer.
IL1RL1 undergoes glycosylation and phosphorylation.
IL1RL1 expression is upregulated in asthmatic conditions.
Customer Reviews (3)
Write a reviewHigh specificity in ELISA.
Suitable for flow cytometry.
Effective in allergy models.
Ask a Question for All IL1RL1 Products
Required fields are marked with *
My Review for All IL1RL1 Products
Required fields are marked with *
Inquiry Basket