Recombinant Human Interleukin 13 Receptor, Alpha 2

• Cat.No.: IL13RA2-1651H

Specification

• Cat. No.: IL13RA2-1651H
• Description: Interleukin 13 receptor alpha 2, also known as IL13RA2 and CD213A2, binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. IL13RA2 serves as a dominant negative inhibitor or a decoy receptor for IL-13. IL-13Ralpha2 is a promising target for ovarian cancer therapy, and the soluble form of IL-13R may be a possible surrogate marker for disease monitoring. IL13RA2 signaling during prolonged inflammation is also an important therapeutic target for the prevention of TGF-beta(1)-mediated fibrosis.
• Molecular Weight: The predicted molecular weight of Recombinant Human IL-13 Rα2 is Mr 65 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 74 kDa.
• Source: Sf 21 Insect Cells.
• State Of Matter: Lyophilized.
• Purity: >90% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: IL13RA2 interleukin 13 receptor, alpha 2 [ Homo sapiens ]
• Synonyms: IL13RA2; interleukin 13 receptor, alpha 2; CT19; IL-13R; IL13BP; CD213A2; OTTHUMP00000023871; cancer/testis antigen 19; interleukin 13 binding protein; interleukin 13 receptor alpha 2 chain; IL-13 receptor; CD213a2; IL13R; OTTHUMP00000023871; CD213a2 antigen; Interleukin-13-binding protein
• Gene ID: 3598
• mRNA Refseq: NM_000640
• Protein Refseq: NP_000631
• MIM: 300130
• UniProt ID: Q14627
• Chromosome Location: Xq13.1-q28
• Pathway: Jak-STAT signaling pathway
• Function: cytokine receptor activity; receptor activity

Reviews

07/14/2019

Reliable in co-immunoprecipitation.

09/24/2018

High specificity.

01/05/2017

Effective in asthma models.

Q&As

What experimental methods determine IL13RA2's role in cancer metastasis?

Methods unveil IL13RA2's role in cancer metastasis.

How does proximity ligation assay reveal IL13RA2 interactions with other proteins?

Proximity ligation assay exposes IL13RA2 interactions with proteins.

Can you elaborate on the use of immunohistochemistry in studying IL13RA2 expression in tissues?

Immunohistochemistry maps IL13RA2 expression in tissues.

How do structural studies such as X-ray crystallography inform IL13RA2's ligand binding mechanism?

Structural studies like X-ray crystallography illuminate IL13RA2's ligand binding mechanism.

What are the advantages of using siRNA libraries to explore IL13RA2 functions?

siRNA libraries probe diverse IL13RA2 functions advantageously.

Could you describe how CRISPR screening identifies regulators of IL13RA2 expression?

CRISPR screening identifies regulators of IL13RA2 expression.

What techniques investigate IL13RA2 dimerization in cellular contexts?

Techniques reveal IL13RA2 dimerization in cellular settings.

Could you explain how mass spectrometry identifies IL13RA2 post-translational modifications?

Mass spectrometry detects IL13RA2 post-translational modifications.

How does surface plasmon resonance (SPR) analyze IL13RA2 binding affinities?

SPR quantifies IL13RA2 binding affinities with precision.

How do reporter gene assays assess IL13RA2-mediated signaling pathways?

Reporter gene assays illuminate IL13RA2-mediated signaling.