Description : |
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
51.8 kDa |
AA Sequence : |
MNLEGGGRGGEFGMSAVSCGNGKLR QWLIDQIDSGKYPGLVWENEEKSIF RIPWKHAGKQDYNREEDAALFKAWA LFKGKFREGIDKPDPPTWKTRLRCA LNKSNDFEELVERSQLDISDPYKVY RIVPEGAKKGAKQLTLEDPQMSMSH PYTMTTPYPSLPAQQVHNYMMPPLD RSWRDYVPDQPHPEIPYQCPMTFGP RGHHWQGPACENGCQVTGTFYACAP PESQAPGVPTEPSIRSAEALAFSDC RLHICLYYREILVKELTTSSPEGCR ISHGHTYDASNLDQVLFPYPEDNGQ RKNIEKLLSHLERGVVLWMAPDGLY AKRLCQSRIYWDGPLALCNDRPNKL ERDQTCKLFDTQQFLSELQAFAHHG RSLPRFQVTLCFGEEFPDPQRQRKL ITAHVEPLLARQLYYFAQQNSGHFL RGYDLPEHISNPEDYHRSIRHSSIQ ETRTRPLEQKLISEEDLAANDILDY KDDDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |