Recombinant Human Lnterleukin 32, His-tagged

• Cat.No.: IL32-108H
• Product Overview: Recombinant human Interleukin 32, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography,19.1 kDa (168aa).

Specification

• Cat. No.: IL32-108H
• Description: Interleukin 32 isoform A belongs to cytokine family. This protein expression is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. It has the ability to induce proinflammatory cytokines such as TNFα and IL8 in THP1 cells, and activates typical cytokine signaling pathways involving NFκB and p38. IL-32 can also support osteoclast differentiation but not osteoclast activation by regulating the MAPK/ERK pathway and the actin cytoskeleton.
• Sequences of amino acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMCF PKVLSDDMKK LKARMHQAIE RFYDKMQNAE SGRGQVMSSL AELEDDFKEG YLETVAAYYE EQHPELTPLL EKERDGLRCR GNRSPVPDVE DPATEEPGES FCDKSYGAPR GDKEELTPQK CSEPQSSK
• Formulation: Liquid. In20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol
• Purity: > 95% by SDS - PAGE
• Concentration: 1 mg/ml (determined byBradford assay)
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: interleukin 32 [ Homo sapiens ]
• Synonyms: IL32; interleukin 32;NK4; TAIF; TAIFa; TAIFb; TAIFc; TAIFd; IL-32beta; IL-32alpha; IL-32delta; IL-32gamma; natural killer cells protein 4; natural killer cell transcript 4; tumor necrosis factor alpha-inducing factor
• Gene ID: 9235
• mRNA Refseq: NM_001012631
• Protein Refseq: NP_001012649
• MIM: 606001
• UniProt ID: P24001
• Chromosome Location: 16p13.3
• Function: cytokine activity

Reviews

12/13/2022

IL32 protein has a long shelf life, which facilitates the continuity of subsequent experiments.

05/20/2022

Consistent results can be obtained using IL32 experiments and experimental uncertainty can be reduced.

10/26/2019

The IL32 shows excellent stability and repeatability under specific experimental conditions.

Q&As

Can recombinant IL32 be used to treat autoimmune diseases?

At present, research is ongoing, and IL32 is considered to have the potential to treat autoimmune diseases, but further clinical validation is required.

What is IL32?

IL32, a protein of human origin, is an interferon-induced cytokine with a variety of biological functions.

What is the progress of IL32 in clinical trials?

IL32 is in clinical trials and will take time to evaluate its safety and efficacy.

Is recombinant IL32 associated with inflammation?

IL32 induce and regulate inflammatory response and participate in immune and inflammatory processes.

Can IL32 improve immunity?

Can enhance the activity and function of immune cells, thereby improving the body immunity.

What are the side effects of IL32?

So far, there have been no clear reports of side effects of IL32, but attention should be paid to reasonable dosage and method of use when using it.