Recombinant Human LRRC8 Mutant (R262W）Protein, Myc/DDK-tagged

• Cat.No.: LRRC8A-057H
• Product Overview: Purified mutant recombinant protein of Human SH2B adaptor protein 3 (SH2B3), mutation at (R262W) with a Myc/DDK tag was expressed in HEK293

Specification

• Description: This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. This family member is a putative four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 94.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for at least 12 months from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: > 50 μg/mL as determined by microplate Bradford method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Gene Information

• Gene Name: LRRC8A leucine rich repeat containing 8 VRAC subunit A [ Homo sapiens (human) ]
• Official Symbol: LRRC8A
• Synonyms: LRRC8A; leucine rich repeat containing 8 VRAC subunit A; AGM5; LRRC8; SWELL1; volume-regulated anion channel subunit LRRC8A; leucine rich repeat containing 8 family member A; leucine-rich repeat-containing protein 8A; swelling protein 1
• Gene ID: 56262
• mRNA Refseq: NM_019594
• Protein Refseq: NP_062540
• MIM: 608360
• UniProt ID: Q8IWT6