Recombinant Human MCM6
Cat.No. : | MCM6-28042TH |
Product Overview : | Recombinant full length Human MCM6 (aa 1-821) with N-terminal proprietary tag, 116.38 kDa. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. |
Protein length : | 821 amino acids |
Molecular Weight : | 116.380kDa inclusive of tags |
Source : | Wheat germ |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage buffer : | pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | MDLAAAAEPGAGSQHLEVRDEVAEKCQKLFLDFLEEFQSS DGEIKYLQLAEELIRPERNTLVVSFVDLEQFNQQLSTTIQ EEFYRVYPYLCRALKTFVKDRKEIPLAKDFYVAFQDLPTR HKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLD CQTVIRDVEQQFKYTQPNICRNPVCANRRRFLLDTNKSRF VDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGD KCDFTGTLIVVPDVSKLSTPGARAETNSRVSGVDGYETEG IRGLRALGVRDLSYRLVFLACCVAPTNPRFGGKELRDEEQ TAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHG NDEVKRGVLLMLFGGVPKTTGEGTSLRGDINVCIVGDPST AKSQFLKHVEEFSPRAVYTSGKASSAAGLTAAVVRDEESH EFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQ TISITKAGVKATLNARTSILAAANPISGHYDRSKSLKQNI NLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRIE ESIDRVYSLDDIRRYLLFARQFKPKISKESEDFIVEQYKH LRQRDGSGVTKSSWRITVRQLESMIRLSEAMARMHCCDEV QPKHVKEAFRLLNKSIIRVETPDVNLDQEEEIQMEVDEGA GGINGHADSPAPVNGINGYNEDINQESAPKASLRLGFSEY CRISNLIVLHLRKVEEEEDESALKRSELVNWYLKEIESEI DSEEELINKKRIIEKVIHRLTHYDHVLIELTQAGLKGSTE GSESYEEDPYLVVNPNYLLED |
Sequence Similarities : | Belongs to the MCM family.Contains 1 MCM domain. |
Gene Name : | MCM6 minichromosome maintenance complex component 6 [ Homo sapiens ] |
Official Symbol : | MCM6 |
Synonyms : | MCM6; minichromosome maintenance complex component 6; MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) , minichromosome maintenance deficient (mis5, S. pombe) 6 , minichromosome maintenance deficient 6 homolog (S. cer |
Gene ID : | 4175 |
mRNA Refseq : | NM_005915 |
Protein Refseq : | NP_005906 |
MIM : | 601806 |
Uniprot ID : | Q14566 |
Chromosome Location : | 2q14-q21 |
Pathway : | Activation of ATR in response to replication stress, organism-specific biosystem; Activation of the pre-replicative complex, organism-specific biosystem; Assembly of the pre-replicative complex, organism-specific biosystem; Cell Cycle Checkpoints, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; |
Function : | ATP binding; contributes_to ATP-dependent DNA helicase activity; DNA binding; hydrolase activity; identical protein binding; |
Products Types
◆ Recombinant Protein | ||
MCM6-4519H | Recombinant Human MCM6 Protein, GST-tagged | +Inquiry |
MCM6-5414M | Recombinant Mouse MCM6 Protein, His (Fc)-Avi-tagged | +Inquiry |
Mcm6-3997M | Recombinant Mouse Mcm6 Protein, Myc/DDK-tagged | +Inquiry |
MCM6-2525R | Recombinant Rhesus Macaque MCM6 Protein, His (Fc)-Avi-tagged | +Inquiry |
MCM6-2705R | Recombinant Rhesus monkey MCM6 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
MCM6-4416HCL | Recombinant Human MCM6 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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