Recombinant Human MCT1, GST-tagged

• Cat.No.: MCT1-788H
• Product Overview: Recombinant Human MCT1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: C-50aa
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: SLC16A1?solute carrier family 16 (monocarboxylate transporter), member 1 [?Homo sapiens?(human) ]
• Official Symbol: SLC16A1
• Synonyms: SLC16A1; MCT; HHF7; MCT1; solute carrier family 16 (monocarboxylate transporter), member 1; monocarboxylate transporter 1; MCT 1; solute carrier family 16 member 1; solute carrier family 16 (monocarboxylic acid transporters), member 1; solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
• Gene ID: 6566
• mRNA Refseq: NM_001166496
• Protein Refseq: NP_001159968
• MIM: 600682
• UniProt ID: P53985
• Chromosome Location: 1p12
• Pathway: Basigin interactions; Cell surface interactions at the vascular wall; Proton-coupled monocarboxylate transport
• Function: mevalonate transmembrane transporter activity; monocarboxylic acid transmembrane transporter activity; secondary active monocarboxylate transmembrane transporter activity

Reviews

12/02/2021

Their prompt assistance and prompt response can swiftly resolve any challenges, enabling smooth experimentation and maintaining the integrity of the results.

09/01/2021

They keep up with the latest research findings and continually refine their product based on customer feedback and emerging scientific trends.

06/24/2017

Their knowledgeable support team is well-equipped to address specific inquiries, suggest experimental protocols, and provide guidance throughout the entire research process.

Q&As

Are there any genetic disorders associated with MCT1 protein?

Yes, mutations in the SLC16A1 gene that encodes MCT1 protein have been associated with certain metabolic disorders, such as exercise-induced hyperinsulinism.

What methods are used to study MCT1 protein in clinical research?

Various techniques such as immunohistochemistry, western blotting, and gene expression analysis are used to study the expression and activity of MCT1 protein in clinical research.

Can MCT1 protein impact exercise performance?

Yes, MCT1 is involved in lactate transport in muscle cells, which can affect exercise performance and endurance.

How is MCT1 protein involved in cancer metabolism?

MCT1 facilitates the uptake of lactate by cancer cells, which can then be used as an energy source. This is known as the lactate shuttle hypothesis and has implications for cancer growth and progression.

Are there any clinical implications of MCT1 protein in cancer treatment?

Yes, targeting MCT1 protein has been explored as a potential therapeutic strategy for cancer treatment, particularly in combination with other targeted therapies.