Recombinant Human NCOR1, FLAG-tagged
Cat.No. : | NCOR1-28430TH |
Product Overview : | Recombinant full length human Nuclear Receptor Corepressor NCoR with DDDDK tag expressed in Baculovirus system; amino acids 1-2440, 270kDa. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20. |
Conjugation : | FLAG |
Biological activity : | NCOR1-28430TH has been tested for deacetylation activity in vitro in the presence of HDAC3. |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 20% Glycerol, 20mM Tris Cl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the N-CoR nuclear receptor corepressors family.Contains 2 SANT domains. |
Gene Name : | NCOR1 nuclear receptor corepressor 1 [ Homo sapiens ] |
Official Symbol : | NCOR1 |
Synonyms : | NCOR1; nuclear receptor corepressor 1; nuclear receptor co repressor 1; hCIT529I10; hN CoR; KIAA1047; MGC104216; N CoR; thyroid hormone and retinoic acid receptor associated corepressor 1; TRAC1; |
Gene ID : | 9611 |
mRNA Refseq : | NM_001190438 |
Protein Refseq : | NP_001177367 |
MIM : | 600849 |
Uniprot ID : | O75376 |
Chromosome Location : | 17p11.2 |
Pathway : | Adipogenesis, organism-specific biosystem; BMAL1:CLOCK/NPAS2 Activates Gene Expression, organism-specific biosystem; C-MYB transcription factor network, organism-specific biosystem; Circadian Clock, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; |
Function : | histone deacetylase binding; histone deacetylase regulator activity; protein binding; retinoid X receptor binding; sequence-specific DNA binding; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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