Recombinant Human NDRG1, His-tagged

• Cat.No.: NDRG1-30371TH
• Product Overview: Recombinant full length Human NDRG1 fused to a His tag at the C-terminal; 402 amino acids, MWt 43.9kDa.

Specification

• Description: This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. It is necessary for p53-mediated caspase activation and apoptosis. Mutation in this gene has been reported to be causative for hereditary motor and sensory neuropathy-Lom. Multiple alternatively spliced variants, encoding the same protein, have been identified.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Ubiquitous; expressed most prominently in placental membranes and prostate, kidney, small intestine, and ovary tissues. Reduced expression in adenocarcinomas compared to normal tissues. In colon, prostate and placental membranes, the cells that border the
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, 0.1mM PMSF, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MSREMQDVDL AEVKPLVEKG ETITGLLQEF DVQEQDIETL HGSVHVTLCG TPKGNRPVIL TYHDIGMNHK TCYNPLFNYE DMQEITQHFA VCHVDAPGQQ DGAASFPAGY MYPSMDQLAE MLPGVLQQFG LKSIIGMGTG AGAYILTRFA LNNPEMVEGL VLINVNPCAE GWMDWAASKI SGWTQALPDM VVSHLFGKEE MQSNVEVVHT YRQHIVNDMN PGNLHLFINA YNSRRDLEIE RPMPGTHTVT LQCPALLVVG DSSPAVDAVV ECNSKLDPTK TTLLKMADCG GLPQISQPAK LAEAFKYFVQ GMGYMPSASM TRLMRSRTAS GSSVTSLDGT RSRSHTSEGT RSRSHTSEGT RSRSHTSEGA HLDITPNSGA AGNSAGPKSM EVSCLEHHHH HH
• Sequence Similarities: Belongs to the NDRG family.

Gene Information

• Gene Name: NDRG1 N-myc downstream regulated 1 [ Homo sapiens ]
• Official Symbol: NDRG1
• Synonyms: NDRG1; N-myc downstream regulated 1; CAP43; protein NDRG1; DRG1; NDR1; RTP; TDD5
• Gene ID: 10397
• mRNA Refseq: NM_001135242
• Protein Refseq: NP_001128714
• MIM: 605262
• Uniprot ID: Q92597
• Chromosome Location: 8q24
• Pathway: Direct p53 effectors, organism-specific biosystem; HIF-1-alpha transcription factor network, organism-specific biosystem; Validated targets of C-MYC transcriptional repression, organism-specific biosystem
• Function: Rab GTPase binding; cadherin binding; gamma-tubulin binding; microtubule binding; protein binding

Reviews

11/22/2020

Their expertise and assistance have been invaluable in troubleshooting and providing insightful solutions, greatly enhancing the progress of my experiments.

08/26/2020

They have proven to be a timely and reliable resource, readily addressing any concerns or challenges that arise during my research.

06/05/2018

The NDRG1 Protein's superior stability and functional performance render it an indispensable tool for a wide range of scientific investigations.

Q&As

Can NDRG1 be targeted for personalized medicine approaches?

Yes, understanding the individual's NDRG1 expression profile may enable personalized treatment strategies, especially in cancer therapy.

Are there therapeutic implications for modulating NDRG1 expression in cancer treatment?

Are there therapeutic implications for modulating NDRG1 expression in cancer treatment?

Are there clinical trials investigating the use of NDRG1-related therapies?

Yes, there are ongoing clinical trials exploring the safety and efficacy of NDRG1-targeted therapies in various diseases, reflecting the growing interest in its clinical applications.

How does NDRG1 contribute to cellular stress response?

NDRG1 is involved in cellular responses to various stresses, including oxidative stress and DNA damage, playing a role in maintaining cellular homeostasis.

How does NDRG1 affect cardiovascular health?

NDRG1 is involved in processes related to cardiac hypertrophy and response to ischemic stress, making it relevant to cardiovascular diseases.