Recombinant Human NR4A3 (376S) Protein, His tagged

• Cat.No.: NR4A3-03H
• Product Overview: Recombinant Human NR4A3 (376S) Protein with His-tag was expressed in E. coli.

Specification

• Description: This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene.
• Source: E. coli
• Species: Human
• Tag: His
• AA Sequence: MPCVQAQYSPSPPGSSYAAQTYSSE YTTEIMNPDYTKLTMDLGSTEITAT ATTSLPSISTFVEGYSSNYELKPSC VYQMQRPLIKVEEGRAPSYHHHHHH HHHHHHHHQQQHQQPSIPPASSPED EVLPSTSMYFKQSPPSTPTTPAFPP QAGALWDEALPSAPGCIAPGPLLDP PMKAVPTVAGARFPLFHFKPSPPHP PAPSPAGGHHLGYDPTAAAALSLPL GAAAAAGSQAAALESHPYGLPLAKR AAPLAFPPLGLTPSPTASSLLGESP SLPSPPSRSSSSGEGTCAVCGDNAA CQHYGVRTCEGCKGFFKRTVQKNAK YVCLANKNCPVDKRRRNRCQYCRFQ KCLSVGMVKEVVRTDSLKGRRGRLP AKPKSPLQQEPSQPSPPSPPICMMN ALVRALTDSTPRDLDYSRYCPTDQA AAGTDAEHVQQFYNLLTASIDVSRS WAEKIPGFTDLPKEDQTLLIESAFL ELFVLRLSIRSNTAEDKFVFCNGLV LHRLQCLRGFGEWLDSIKDFSLNLQ SLNLDIQALACLSALSMITERHGLK EPKRVEELCNKITSSLKDHQSKGQA LEPTESKVLGALVELRKICTLGLQR IFYLKLEDLVSPPSIIDKLFLDTLP F
• Purity: > 85% by SDS-PAGE
• Storage: Long Term Storage at -20 to -80 centigrade. Avoid freeze/thaw cycles.
• Concentration: 0.2 mg/mL
• Storage Buffer: PBS, pH 7.4

Gene Information

• Gene Name: NR4A3 nuclear receptor subfamily 4, group A, member 3 [ Homo sapiens (human) ]
• Official Symbol: NR4A3
• Synonyms: NR4A3; nuclear receptor subfamily 4, group A, member 3; nuclear receptor subfamily 4 group A member 3; CHN; CSMF; MINOR; NOR1; nuclear hormone receptor NOR-1; neuron-derived orphan receptor 1; mitogen-induced nuclear orphan receptor; translocated in extraskeletal chondrosarcoma; chondrosarcoma, extraskeletal myxoid, fused to EWS; TEC
• Gene ID: 8013
• mRNA Refseq: NM_006981
• Protein Refseq: NP_008912
• MIM: 600542
• UniProt ID: Q92570