Recombinant Human Platelet-Derived Growth Factor Receptor, Beta Polypeptide, His-tagged
Cat.No. : | PDGFRB-1890H |
Product Overview : | Recombinant humanPDGFRB catalytic domain (amino acids 558-1106), His-tagged was expressed ininsect cells. Its molecular weight is 66300 Dalton. |
- Specification
- Gene Information
- Related Products
Cat. No. : | PDGFRB-1890H |
Description : | PDGFRB is a receptortyrosine kinase and has been implicated in atherogenesis and in celltransformation by the SIS oncogene. No special measures were taken toactivate this kinase. PDGFRB encodes a cell surface tyrosine kinase receptorfor members of the platelet-derived growth factor family. These growthfactors are mitogens for cells of mesenchymal origin. The identity of thegrowth factor bound to a receptor monomer determines whether the functionalreceptor is a homodimer or a heterodimer, composed of both platelet-derivedgrowth factor receptor alpha and beta polypeptides. PDGFRB is flanked onchromosome 5 by the genes for granulocyte-macrophage colony-stimulatingfactor and macrophage-colony stimulating factor receptor; all three genes maybe implicated in the 5-q syndrome. |
Source : | Insect cells |
Species : | Human |
Form : | Liquid in 50 mMTris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mM DTT +50% glycerol. |
Molecular Weight : | 66.3 kDa |
Storage : | Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles. |
OfficialSymbol : | PDGFRB |
Gene Name : | PDGFRB platelet-derived growth factorreceptor, beta polypeptide [ Homo sapiens ] |
Synonyms : | PDGFRB;platelet-derived growth factor receptor, beta polypeptide; JTK12; PDGFR;CD140B; PDGFR1; platelet-derived growth factor receptor beta; PDGF-R-beta;CD140 antigen-like family member B; EC 2.7.10.1; CD140b; PDGF-R-beta; CD140bantigen; soluble PDGFRb variant; Beta-type platelet-derived growth factorreceptor |
Gene ID : | 5159 |
mRNA Refseq : | NM_002609 |
Protein Refseq : | NP_002600 |
MIM : | 173410 |
UniProt ID : | P09619 |
Chromosome Location : | 5q33.1 |
Pathway : | Calcium signalingpathway; Cytokine-cytokine receptor interaction; Downstream signaltransduction; Focal adhesion; Gap junction; Glioma; HTLV-I infection; MAPKsignaling pathway; Melanoma; Pathways in cancer; PDGFR-alpha signalingpathway; Regulation of actin cytoskeleton; Signaling by PDGF; S1P1 pathway;S1P3 pathway |
Function : | ATP binding; growthfactor binding; nucleotide binding; platelet activating factor receptoractivity; platelet-derivedgrowth factor alpha-receptor activity; platelet-derived growth factorbinding; platelet-derived growth factor receptor binding; proteinhomodimerization activity; platelet-derived growth factor-activated receptoractivity; protein binding; protein tyrosine kinase activity; receptoractivity; receptor bingding; signal transducer activity; vascular endothelialgrowth factor-activated receptor activity |
Products Types
◆ Recombinant Protein | ||
PDGFRB-271H | Recombinant Human PDGFRB Protein (ECD) (Glu241Asp), Fc-His-tagged(C-ter) | +Inquiry |
PDGFRB-4000R | Recombinant Rat PDGFRB Protein, His (Fc)-Avi-tagged | +Inquiry |
PDGFRB-129H | Recombinant Human PDGFRB Protein (33-532aa), C-hIgG-His tagged | +Inquiry |
Pdgfrb-4759M | Recombinant Mouse Pdgfrb Protein, Myc/DDK-tagged | +Inquiry |
Pdgfrb-10607M | Recombinant Mouse Pdgfrb Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
PDGFRB-1107HCL | Recombinant Human PDGFRB cell lysate | +Inquiry |
PDGFRB-1046CCL | Recombinant Cynomolgus PDGFRB cell lysate | +Inquiry |
PDGFRB-1112RCL | Recombinant Rat PDGFRB cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1618 | PDGFRb Functional Assay Kit | +Inquiry |
Kit-1617 | U2OS PDGFRb Bioassay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket