Recombinant Human PPM1G Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: PPM1G-5767H
• Product Overview: PPM1G MS Standard C13 and N15-labeled recombinant protein (NP_002698) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 59.3 kDa
• AA Sequence: MGAYLSQPNTVKCSGDGVGAPRLPL PYGFSAMQGWRVSMEDAHNCIPELD SETAMFSVYDGHGGEEVALYCAKYL PDIIKDQKAYKEGKLQKALEDAFLA IDAKLTTEEVIKELAQIAGRPTEDE DEKEKVADEDDVDNEEAALLHEEAT MTIEELLTRYGQNCHKGPPHSKSGG GTGEEPGSQGLNGEAGPEDSTRETP SQENGPTAKAYTGFSSNSERGTEAG QVGEPGIPTGEAGPSCSSASDKLPR VAKSKFFEDSEDESDEAEEEEEDSE ECSEEEDGYSSEEAENEEDEDDTEE AEEDDEEEEEEMMVPGMEGKEEPGS DSGTTAVVALIRGKQLIVANAGDSR CVVSEAGKALDMSYDHKPEDEVELA RIKNAGGKVTMDGRVNGGLNLSRAI GDHFYKRNKNLPPEEQMISALPDIK VLTLTDDHEFMVIACDGIWNVMSSQ EVVDFIQSKISQRDENGELRLLSSI VEELLDQCLAPDTSGDGTGCDNMTC IIICFKPRNTAELQPESGKRKLEEV LSTEGAEENGNSDKKKKAKRDTRTR PLEQKLISEEDLAANDILDYKDDDD KV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: PPM1G protein phosphatase, Mg2+/Mn2+ dependent 1G [ Homo sapiens (human) ]
• Official Symbol: PPM1G
• Synonyms: PPM1G; protein phosphatase, Mg2+/Mn2+ dependent, 1G; protein phosphatase 1G (formerly 2C), magnesium dependent, gamma isoform; protein phosphatase 1G; PP2C; gamma; PP2CG; PP2Cgamma; protein phosphatase 2C; gamma isoform; PP2C-gamma; PP2C, gamma; protein phosphatase 1C; protein phosphatase 2C gamma isoform; protein phosphatase 2C isoform gamma; protein phosphatase magnesium-dependent 1 gamma; protein phosphatase 2, catalytic subunit, gamma isoform; protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform; PPP2CG; PP2CGAMMA; MGC1675; MGC2870
• Gene ID: 5496
• mRNA Refseq: NM_002707
• Protein Refseq: NP_002698
• MIM: 605119
• UniProt ID: O15355

Reviews

11/14/2022

PPM1G protein's utility in protein electron microscopy structure analysis is commendable.

12/03/2019

It enables researchers to delve deeper into the intricacies of protein behavior and aids in advancing our knowledge in various fields, such as molecular biology, biochemistry, and structural biology.

11/11/2019

It demonstrates excellent performance in ELISA assays, making it an ideal choice for researchers studying protein-protein interactions, antibody detection, or biomarker identification.

Q&As

Can PPM1G be targeted for cancer treatment?

Research is ongoing to explore the therapeutic potential of targeting PPM1G in cancer. Inhibiting or modulating its activity may be a strategy for cancer therapy.

Are there any known associations between PPM1G and cancer?

Yes, abnormal expression of PPM1G has been linked to certain cancers, suggesting its potential role as a biomarker or therapeutic target.

Are there any genetic disorders associated with PPM1G mutations?

While rare, mutations in the PPM1G gene have been reported and may be associated with certain genetic disorders. Further research is needed to understand the implications.

How does PPM1G contribute to DNA repair mechanisms?

PPM1G is involved in the regulation of DNA repair processes, influencing the repair of damaged DNA and maintaining genomic stability.

Can PPM1G be used as a diagnostic marker for specific diseases?

PPM1G expression levels may serve as a diagnostic marker for certain diseases, including some cancers, but more studies are required to establish its diagnostic utility.