Recombinant Human PPP3CB Protein, His&GST-tagged

• Cat.No.: PPP3CB-1973H
• Product Overview: Recombinant Human PPP3CB Protein (Thr360-Gln524) with N-His&GST tag was expressed in E. coli.

Specification

• Description: Enables several functions, including calmodulin binding activity; calmodulin-dependent protein phosphatase activity; and protein phosphatase 2B binding activity. Involved in calcineurin-NFAT signaling cascade; positive regulation of transcription by RNA polymerase II; and protein dephosphorylation. Located in cytoplasm. Part of calcineurin complex. Implicated in aortic valve stenosis. Biomarker of focal segmental glomerulosclerosis and schizophrenia.
• Source: E. coli
• Species: Human
• Tag: N-His&GST
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 48 kDa
  Accurate Molecular Mass: 48 kDa
• Protein length: Thr360-Gln524
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme [ Homo sapiens (human) ]
• Official Symbol: PPP3CB
• Synonyms: PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme; CALNB, protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform, protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta); serine/threonine-protein phosphatase 2B catalytic subunit beta isoform; calcineurin A beta; CALNA2; CNA2; PP2Bbeta; protein phosphatase 2B; catalytic subunit; beta isoform; calcineurin A2; CAM-PRP catalytic subunit; protein phosphatase from PCR fragment H32; calmodulin-dependent calcineurin A subunit beta isoform; protein phosphatase 2B, catalytic subunit, beta isoform; protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform; CALNB
• Gene ID: 5532
• mRNA Refseq: NM_001142353
• Protein Refseq: NP_001135825
• MIM: 114106
• UniProt ID: P16298