Recombinant Human Protein Tyrosine Phosphatase, Receptor Type, N, GST-tagged
Cat.No. : | PTPRN-1307H |
Product Overview : | Recombinanthuman PTPRN is expressed in E. coli; it contains the catalyticdomain of PTPRN (residues 693-979), with aN-terminal GST tag, and has a molecular weight of 58.8 kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : | PTPRN-1307H |
Description : | PTPRN (proteintyrosine phosphatase-IA2; also known as ICA-512), together with PTP-IAR,belongs to a subgroup of receptor-like protein tyrosine phosphatases. PTPRNwas found to be an autoantigen that is reactive with insulin-dependentdiabetes mellitus (IDDM) patient sera, and thus may be a potential target ofautoimmunity in diabetes mellitus. It is highly expressed in neuroendocrinetissues. Human PTPRN is a receptor protein tyrosine phosphatase containing979 amino acids. |
Source : | E. coli |
Species : | Human |
Form : | 25 mMTris-HCl (pH 8.0), 75 mM NaCl, 0.05% Tween-20, 2 mM EDTA, 1 mM DTT and 50%glycerol. Liquid at -20°C. |
Purity : | Greaterthan 95% as determined by Coomassie-stained SDS-PAGE gel. |
Specific Activity : | 1.4U/ug. One unit will hydrolyze 1 pmol of 6, 8-difluoro-4-methyl umbelliferylphosphate (DiFMUP) per minute at pH 6.3 and 30°C. Assay buffer: 50 mMBis-Tris (pH 6.3), 2 mM EDTA, 2 mM DTT and 100 mM DiFMUP. |
Applications : | Removal ofphosphates from target substrates. Useful for the study of enzyme kinetics,regulation and for inhibitors screening. |
Storage : | 3 monthsat -20°C. |
OfficialSymbol : | PTPRN |
Pathways : | Type I diabetesmellitus |
Gene Name : | PTPRN protein tyrosine phosphatase,receptor type, N [ Homo sapiens ] |
Synonyms : | PTPRN; proteintyrosine phosphatase, receptor type, N; IA2; IA-2; ICA512;R-PTP-N; IA-2/PTP; receptor-type tyrosine-protein phosphatase-like N; ICA 512;PTP IA-2; OTTHUMP00000164170; OTTHUMP00000205824; islet cell antigen 2; isletcell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-likeN |
Gene ID : | 5798 |
mRNA Refseq : | NM_001199763 |
Protein Refseq : | NP_001186692 |
MIM : | 601773 |
UniProt ID : | Q16849 |
Chromosome Location : | 2q35-q36.1 |
Function : | GTPase binding;hydrolase activity; phosphatase activity; protein binding; protein tyrosinephosphatase activity; receptor activity; transmembrane receptor proteintyrosine phosphatase activity |
Products Types
◆ Recombinant Protein | ||
PTPRN-674H | Recombinant Human PTPRN Protein, DDK-tagged | +Inquiry |
PTPRN-4500R | Recombinant Rat PTPRN Protein, His (Fc)-Avi-tagged | +Inquiry |
PTPRN-256H | Recombinant Human PTPRN Protein, Flag-tagged | +Inquiry |
PTPRN-02H | Recombinant Human IA2 Protein, GST-tagged | +Inquiry |
PTPRN-8H | Recombinant Human PTPRN Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
PTPRN-1440HCL | Recombinant Human PTPRN cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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