Recombinant Human PTPRF, GST-tagged, Active

• Cat.No.: PTPRF-469H
• Product Overview: Recombinant human PTPRF (1275-1897) was expressed inE.Coliusing an N-terminal GST tag. MW=93kDa.

Specification

• Cat. No.: PTPRF-469H
• Description: PTPRF or LAR is a member of the protein tyrosine phosphatase family with an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains. PTPRF has been shown to function in the regulation of epithelial cell-cell contacts at adherents junctions as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance.
• Source: E.Coli.
• Sequence: 1275-1897.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• 22q13.33: 1p34

Gene Information

• Gene Name: PTPRF protein tyrosine phosphatase, receptor type, F [ Homo sapiens ]
• Synonyms: PTPRF; protein tyrosine phosphatase, receptor type, F; LCA-homolog; OTTHUMP00000008683; OTTHUMP00000008684; leukocyte antigen-related (LAR) PTP receptor; leukocyte antigen-related tyrosine phosphatase; protein tyrosine phosphatase, receptor type, F polypeptide; receptor-linked protein-tyrosine phosphatase LAR; LAR; FLJ43335; FLJ45062; FLJ45567; EC 3.1.3.48
• Gene ID: 5792
• mRNA Refseq: NM_002840
• Protein Refseq: NP_002831
• MIM: 179590
• UniProt ID: P10586
• Pathway: Adherens junction; Cell adhesion molecules (CAMs); Insulin signaling pathway
• Function: heparan sulfate proteoglycan binding; heparin binding; hydrolase activit; protein binding; protein kinase binding; transmembrane receptor protein tyrosine phosphatase activity

Reviews

06/11/2022

Qualitative is very strong, even after a lot of use can still maintain its structural and functional stability, which shows its excellent quality and reliability.

04/13/2022

The reproducibility is very good, and I can get consistent results from each experiment, which makes me more confident in the experimental results.

02/19/2022

Excellent performance in Western blot, avoiding interference problems in the experiment.

Q&As

Do specific PTPRF inhibitors have therapeutic effects on autoimmune diseases?

PTPRF inhibitors can inhibit certain abnormal signaling pathways in autoimmune diseases, thereby exerting their role in the treatment of autoimmune diseases.

What is the therapeutic effect of specific PTPRF inhibitors on inflammatory diseases?

Specific PTPRF inhibitors can inhibit certain signaling pathways in the inflammatory response, thereby playing a role in the treatment of inflammatory diseases.

What is the effect of knocking out the PTPRF gene on tumorigenesis?

Knocking out the PTPRF gene may increase the risk of developing certain tumors, which may be related to aberrant regulation of cell cycle control and cell growth.

Is there a specific PTPRF inhibitor?

There are currently some studies that report specific PTPRF inhibitors that can inhibit the enzymatic activity of PTPRF and thus exert therapeutic effects.

Is there a soluble PTPRF protein?

Yes, soluble PTPRF proteins exist that can be detected in extracellular fluids and may play a role in regulating cell-to-cell communication and signal transduction.

What are the therapeutic strategies for PTPRF protein?

Therapeutic strategies for PTPRF protein include increasing its expression level, inhibiting its enzymatic activity, and regulating its interaction with other proteins, which can be used to treat PTPRF protein-related diseases.