Recombinant Human RAB5A Protein (Asp136-Asn491), His tagged

• Cat.No.: RAB5A-3256H
• Product Overview: Recombinant human Rab5 (Asp136-Asn491) protein fused with His tag was expressed in E. coli.

Specification

• Description: Over-expression of RAB5A gene has been proved to be associated with neoplasia metastasis.Over-expression of RAB5A genes plays an important role in tumor invasion and metastatic phenotype formation of human lung adenocarcinoma cells; and antisense RNA can interrupt the translation of RAB5A gene.RAB5A was a directly target of miR-13a, and its mRNA and protein level was negatively regulated by miR-13a. Immunohistochemistry verified RAB5A was upregulated in breast cancer tissues. RAB5A gene was abnormally expressed in luteinized granulosa cells of obese patients with polycystic ovary syndrome, which may help explain high FSHR levels found in this syndrome.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: 10.83 kDa
• Protein Length: Asp136-Asn491
• Purity: >90 % as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: RAB5A RAB5A, member RAS oncogene family [ Homo sapiens (human) ]
• Official Symbol: RAB5A
• Synonyms: RAB5A; RAB5A, member RAS oncogene family; RAB5; ras-related protein Rab-5A; RAS associated protein RAB5A; RAS-associated protein RAB5A
• Gene ID: 5868
• mRNA Refseq: NM_004162
• Protein Refseq: NP_004153
• MIM: 179512
• UniProt ID: P20339

Reviews

09/12/2021

If researchers require specific variants or modifications of RAB5A protein, the manufacturer can work with them to provide customized products tailored to their needs.

04/11/2020

Their expertise can help troubleshoot problems, suggest alternative approaches, or provide recommendations for optimizing experimental protocols.

06/17/2018

This level of support saves researchers time and resources, enabling them to focus on the scientific aspects of their work and accelerate the overall progress of their studies.

Q&As

Can targeting RAB5A be a therapeutic approach in cancer treatment?

Research suggests that modulating RAB5A activity may be a viable therapeutic strategy in cancer treatment.

How is RAB5A implicated in clinical applications?

RAB5A is associated with various cellular processes, and its dysregulation has been linked to several diseases.

How does RAB5A contribute to neurodegenerative diseases?

RAB5A dysfunction has been implicated in neurodegenerative diseases, affecting vesicle trafficking and cellular homeostasis in neurons.

Are there diagnostic implications of RAB5A in cancer?

Yes, altered levels of RAB5A expression can serve as potential diagnostic markers for certain cancers.

Are there ongoing clinical trials targeting RAB5A in neurodegenerative diseases?

Some clinical trials are exploring interventions targeting RAB5A to assess their potential in managing neurodegenerative conditions.