Recombinant Human RAB5A Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: RAB5A-6255H
• Product Overview: RAB5A MS Standard C13 and N15-labeled recombinant protein (NP_004153) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: RAB5A (RAB5A, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB5A include Motor Neuron Disease and Choroideremia. Among its related pathways are RAB GEFs exchange GTP for GDP on RABs and TBC/RABGAPs. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB5C.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 23.7 kDa
• AA Sequence: MASRGATRPNGPNTGNKICQFKLVL LGESAVGKSSLVLRFVKGQFHEFQE STIGAAFLTQTVCLDDTTVKFEIWD TAGQERYHSLAPMYYRGAQAAIVVY DITNEESFARAKNWVKELQRQASPN IVIALSGNKADLANKRAVDFQEAQS YADDNSLLFMETSAKTSMNVNEIFM AIAKKLPKNEPQNPGANSARGRGVD LTEPTQPTRNQCCSNTRTRPLEQKL ISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: RAB5A RAB5A, member RAS oncogene family [ Homo sapiens (human) ]
• Official Symbol: RAB5A
• Synonyms: RAB5A; RAB5A, member RAS oncogene family; RAB5; ras-related protein Rab-5A; RAS associated protein RAB5A; RAS-associated protein RAB5A
• Gene ID: 5868
• mRNA Refseq: NM_004162
• Protein Refseq: NP_004153
• MIM: 179512
• UniProt ID: P20339

Reviews

09/12/2021

If researchers require specific variants or modifications of RAB5A protein, the manufacturer can work with them to provide customized products tailored to their needs.

04/11/2020

Their expertise can help troubleshoot problems, suggest alternative approaches, or provide recommendations for optimizing experimental protocols.

06/17/2018

This level of support saves researchers time and resources, enabling them to focus on the scientific aspects of their work and accelerate the overall progress of their studies.

Q&As

Can targeting RAB5A be a therapeutic approach in cancer treatment?

Research suggests that modulating RAB5A activity may be a viable therapeutic strategy in cancer treatment.

How is RAB5A implicated in clinical applications?

RAB5A is associated with various cellular processes, and its dysregulation has been linked to several diseases.

How does RAB5A contribute to neurodegenerative diseases?

RAB5A dysfunction has been implicated in neurodegenerative diseases, affecting vesicle trafficking and cellular homeostasis in neurons.

Are there diagnostic implications of RAB5A in cancer?

Yes, altered levels of RAB5A expression can serve as potential diagnostic markers for certain cancers.

Are there ongoing clinical trials targeting RAB5A in neurodegenerative diseases?

Some clinical trials are exploring interventions targeting RAB5A to assess their potential in managing neurodegenerative conditions.