Recombinant Human RAGE protein, GST-tagged

• Cat.No.: RAGE-2163H
• Product Overview: Recombinant Human RAGE (1-231aa) fussed with GST tag at N-terminal was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: GST
• Form: 1M PBS (58 mM Na2HPO4, 17 mM NaH2PO4, 68 mM NaCl, pH8.0 ), 100 mM GSH and 1% Triton X-100, 15% glycerol.
• Molecular Mass: 53 kDa
• Protein length: 1-231aa
• AA Sequence: MKNYKAIGKIGEGTFSEVMKMQSLR DGNYYACKQMKQRFESIEQVNNLRE IQALRRLNPHPNILMLHEVVFDRKS GSLALICELMDMNIYELIRGRRYPL SEKKIMHYMYQLCKSLDHIHRNGIF HRDVKPENILIKQDVLKLGDFGSCR SVYSKQPYTEYISTRWYRAPECLLT DGFYTYKMDLWSAGCVFYEIASLQP LFPGVNELDQISKIHDVIGTPAQKI LTKFKQ
• Stability: Aliquot and store at -20 centigrade to -80 centigrade for up to 6 months. Avoid freeze thaw cycles.
• Shipping: The product is shipped with ice packs. Upon receipt, store it immediately at -20 centigrade to -80 centigrade.

Gene Information

• Gene Name: AGER advanced glycosylation end product-specific receptor [ Homo sapiens ]
• Official Symbol: AGER
• Synonyms: AGER; advanced glycosylation end product-specific receptor; RAGE; RAGE isoform sRAGE-delta; RAGE isoform NtRAGE-delta
• Gene ID: 177
• mRNA Refseq: NM_001136
• Protein Refseq: NP_001127
• MIM: 600214
• UniProt ID: Q15109
• Chromosome Location: 6p21.3
• Pathway: Activated TLR4 signalling, organism-specific biosystem; Advanced glycosylation endproduct receptor signaling, organism-specific biosystem; Cytosolic sensors of pathogen-associated DNA, organism-specific biosystem; DAI mediated induction of type I IFNs, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; MyD88 cascade initiated on plasma membrane, organism-specific biosystem
• Function: S100 alpha binding; advanced glycation end-product receptor activity; protein binding; receptor activity; receptor activity; transmembrane signaling receptor activity

Reviews

02/26/2022

It's quality was evident in consistent results across replicates.

08/13/2021

 Protein consistently upregulated the expression of tissue-specific markers.

01/20/2020

 Gel electrophoresis bands displayed distinct separation, showcasing the product’s purity.

06/22/2019

It’s consistent outcomes supported reliable statistical analysis.

01/11/2017

Consistency and Compatibility Consistency in the product’s performance bolstered the credibility of our research findings.

Q&As

How does AGER affect bone health?

AGER is involved in bone metabolism and might influence osteoporosis and bone diseases.

Are there diagnostic applications for AGER?

AGER levels might serve as biomarkers for certain diseases, including diabetes.

How does AGER interact with AGEs?

AGER binds AGEs, initiating signaling cascades linked to inflammation, oxidative stress, and tissue damage.

How is AGER implicated in skin aging?

AGER contributes to skin aging through oxidative stress and collagen damage.

What is the AGER protein?

AGER stands for "Advanced Glycosylation End-Product Specific Receptor," a cell surface receptor.

Can the AGER protein impact inflammation?

Yes, AGER activation contributes to inflammation and immune responses.

How does AGER impact wound healing?

AGER activation can impair wound healing through inflammation and oxidative stress.

How does AGER influence neurodegenerative diseases?

AGER contributes to neuroinflammation and might play a role in neurodegeneration.

Can AGER influence kidney function?

AGER contributes to diabetic nephropathy and kidney dysfunction.

How does the AGER protein interact with AGEs?

AGER binds to AGEs, initiating cellular signaling pathways linked to inflammation and oxidative stress.

Can AGER influence lung health?

AGER is implicated in lung diseases and inflammation, such as chronic obstructive pulmonary disease.

Are there therapeutic strategies targeting AGER?

Researchers explore compounds that modulate AGER to mitigate its effects.

How is AGER involved in diabetic complications?

AGER contributes to diabetic complications by promoting inflammation and tissue damage.

How is the AGER protein involved in research?

AGER is studied for its implications in aging, diabetes, and various age-related diseases.

What is the function of the AGER protein?

AGER plays a role in mediating cellular responses to advanced glycation end products (AGEs).

Are there dietary interventions for AGER-related effects?

Consuming a low-AGE diet may help reduce AGER activation and its negative effects.

Can AGER impact immune responses?

AGER activation affects immune cell functions and influences immune responses.

Does AGER affect cardiovascular health?

AGER activation is linked to cardiovascular diseases, including atherosclerosis.

Are there other ligands for the AGER protein?

Yes, besides AGEs, AGER interacts with other ligands like HMGB1 and β-amyloid.

Is AGER research ongoing?

Yes, ongoing research aims to uncover new roles and therapeutic targets related to AGER.