Recombinant Human RAPGEF6 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | RAPGEF6-5811H |
Product Overview : | RAPGEF6 MS Standard C13 and N15-labeled recombinant protein (NP_057424) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | RAPGEF6 (Rap Guanine Nucleotide Exchange Factor 6) is a Protein Coding gene. Diseases associated with RAPGEF6 include Schizoid Personality Disorder and Band Heterotopia. Among its related pathways are Ras signaling pathway and Tight junction. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and GTP-dependent protein binding. An important paralog of this gene is ENSG00000273217. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 179.2 kDa |
AA Sequence : | MNSPVDPGARQALRKKPPERTPEDL NTIYSYLHGMEILSNLREHQLRLMS ARARYERYSGNQVLFCSETIARCWY ILLSGSVLVKGSMVLPPCSFGKQFG GKRGCDCLVLEPSEMIVVENAKDNE DSILQREIPARQSRRRFRKINYKGE RQTITDDVEVNSYLSLPADLTKMHL TENPHPQVTHVSSSQSGCSIASDSG SSSLSDIYQATESEVGDVDLTRLPE GPVDSEDDEEEDEEIDRTDPLQGRD LVRECLEKEPADKTDDDIEQLLEFM HQLPAFANMTMSVRRELCSVMIFEV VEQAGAIILEDGQELDSWYVILNGT VEISHPDGKVENLFMGNSFGITPTL DKQYMHGIVRTKVDDCQFVCIAQQD YWRILNHVEKNTHKVEEEGEIVMVH EHRELDRSGTRKGHIVIKATPERLI MHLIEEHSIVDPTYIEDFLLTYRTF LESPLDVGIKLLEWFKIDSLRDKVT RIVLLWVNNHFNDFEGDPAMTRFLE EFEKNLEDTKMNGHLRLLNIACAAK AKWRQVVLQKASRESPLQFSLNGGS EKGFGIFVEGVEPGSKAADSGLKRG DQIMEVNGQNFENITFMKAVEILRN NTHLALTVKTNIFVFKELLFRTEQE KSGVPHIPKIAEKKSNRHSIQHVPG DIEQTSQEKGSKKVKANTVSGGRNK IRKILDKTRFSILPPKLFSDGGLSQ SQDDSIVGTRHCRHSLAIMPIPGTL SSSSPDLLQPTTSMLDFSNPSDIPD QVIRVFKVDQQSCYIIISKDTTAKE VVFHAVHEFGLTGASDTYSLCEVSV TPEGVIKQRRLPDQFSKLADRIQLN GRYYLKNNMETETLCSDEDAQELVK ESQLSMLQLSTIEVATQLSMRDFDL FRNIEPTEYIDDLFKLNSKTGNTHL KRFEDIVNQETFWVASEILTEANQL KRMKIIKHFIKIALHCRECKNFNSM FAIISGLNLASVARLRGTWEKLPSK YEKHLQDLQDIFDPSRNMAKYRNIL SSQSMQPPIIPLFPVVKKDMTFLHE GNDSKVDGLVNFEKLRMISKEIRQV VRMTSANMDPAMMFRQRSLSQGSTN SNMLDVQGGAHKKRARRSSLLNAKK LYEDAQMARKVKQYLSSLDVETDEE KFQMMSLQWEPAYGTLTKNLSEKRS AKSSEMSPVPMRSAGQTTKAHLHQP HRVSQVLQVPAVNLHPIRKKGQTKD PALNTSLPQKVLGTTEEISGKKHTE DTISVASSLHSSPPASPQGSPHKGY TLIPSAKSDNLSDSSHSEISSRSSI VSNCSVDSMSAALQDERCSSQALAV PESTGALEKTEHASGIGDHSQHGPG WTLLKPSLIKCLAVSSSVSNEEISQ EHIIIEAADSGRGSWTSCSSSSHDN FQSLPNPKSWDFLNSYRHTHLDDPI AEVEPTDSEPYSCSKSCSRTCGQCK GSLERKSWTSSSSLSDTYEPNYGTV KQRVLESTPAESSEGLDPKDATDPV YKTVTSSTEKGLIVYCVTSPKKDDR YREPPPTPPGYLGISLADLKEGPHT HLKPPDYSVAVQRSKMMHNSLSRLP PASLSSNLVACVPSKIVTQPQRHNL QPFHPKLGDVTDADSEADENEQVSA VTRTRPLEQKLISEEDLAANDILDY KDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | RAPGEF6 Rap guanine nucleotide exchange factor 6 [ Homo sapiens (human) ] |
Official Symbol : | RAPGEF6 |
Synonyms : | RAPGEF6; Rap guanine nucleotide exchange factor (GEF) 6; PDZ domain containing guanine nucleotide exchange factor (GEF) 2, PDZGEF2; rap guanine nucleotide exchange factor 6; PDZ GEF2; RA GEF 2; PDZ domain-containing guanine nucleotide exchange factor 2; PDZ domain-containing guanine nucleotide exchange factor I; PDZ domain containing guanine nucleotide exchange factor (GEF) 2; RAGEF2; PDZGEF2; KIA001LB; PDZ-GEF2; RA-GEF-2; DKFZp667N084; DKFZp686I15116; |
Gene ID : | 51735 |
mRNA Refseq : | NM_016340 |
Protein Refseq : | NP_057424 |
MIM : | 610499 |
UniProt ID : | Q8TEU7 |
Products Types
◆ Recombinant Protein | ||
RAPGEF6-499H | Recombinant Human RAPGEF6 Protein, MYC/DDK-tagged | +Inquiry |
Rapgef6-5379M | Recombinant Mouse Rapgef6 Protein, Myc/DDK-tagged | +Inquiry |
RAPGEF6-1632H | Recombinant Human RAPGEF6, GST-tagged | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionAnimal models, such as mice with RAPGEF6 gene mutations, are being used to study the impact of RAPGEF6 dysfunction on neurological development and behavior.
RAPGEF6 protein is involved in the regulation of neuronal differentiation, axon guidance, and synaptic plasticity, contributing to proper brain development and function.
Targeting RAPGEF6 protein or its downstream signaling pathways may hold therapeutic potential for certain neurological conditions, but specific interventions are still under investigation.
Genetic testing, such as whole exome sequencing, is employed to identify mutations in the RAPGEF6 gene that may be linked to neurological disorders.
RAPGEF6 has been shown to interact with various proteins involved in synaptic transmission and neuronal signaling, suggesting potential implications in neurological disorders.
Customer Reviews (3)
Write a reviewthe RAPGEF6 protein's high quality and its compatibility with my experimental needs, coupled with the manufacturer's excellent technical support, create a valuable alliance that contributes to successful research endeavors.
The RAPGEF6 protein is characterized by its exceptional quality, making it an ideal choice to fulfill my experimental requirements.
The manufacturer's commitment to providing high-quality proteins is evident in their meticulous production process, ensuring the purity and reliability of the RAPGEF6 protein.
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