Recombinant Human RBM4 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | RBM4-2490H |
Product Overview : | RBM4 MS Standard C13 and N15-labeled recombinant protein (NP_002887) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 40.3 kDa |
AA Sequence : | MVKLFIGNLPREATEQEIRSLFEQY GKVLECDIIKNYGFVHIEDKTAAED AIRNLHHYKLHGVNINVEASKNKSK TSTKLHVGNISPTCTNKELRAKFEE YGPVIECDIVKDYAFVHMERAEDAV EAIRGLDNTEFQGKRMHVQLSTSRL RTAPGMGDQSGCYRCGKEGHWSKEC PIDRSGRVADLTEQYNEQYGAVRTP YTMSYGDSLYYNNAYGALDAYYKRC RAARSYEAVAAAAASVYNYAEQTLS QLPQVQNTAMASHLTSTSLDPYDRH LLPTSGAAATAAAAAAAAAAVTAAS TSYYGRDRSPLRRATAPVPTVGEGY GYGHESELSQASAAARNSLYDMARY EREQYADRARYSAFSGPTRTRPLEQ KLISEEDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | RBM4 RNA binding motif protein 4 [ Homo sapiens (human) ] |
Official Symbol : | RBM4 |
Synonyms : | RBM4; RNA binding motif protein 4; RNA-binding protein 4; LARK; RBM4A; ZCCHC21; ZCRB3A; lark homolog; RNA-binding motif protein 4a; transcriptional coactivator CoAZ; zinc finger CCHC-type and RNA binding motif 3A; FLJ36727; MGC75138; DKFZp547K0918; |
Gene ID : | 5936 |
mRNA Refseq : | NM_002896 |
Protein Refseq : | NP_002887 |
MIM : | 602571 |
UniProt ID : | Q9BWF3 |
Products Types
◆ Recombinant Protein | ||
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RBM4-105H | Recombinant Human RBM4, GST-tagged | +Inquiry |
◆ Lysates | ||
RBM4-531HCL | Recombinant Human RBM4 lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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