Recombinant Human RBP3
Cat.No. : | RBP3-30611TH |
Product Overview : | Recombinant fragment of Human RBP3 with an N-terminal proprietary tag; Predicted MW 36.41 kDa |
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Description : | Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da. The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity, suggesting a series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three exons, which are 191, 143, and approximately 740 base pairs long, respectively. |
Protein length : | 98 amino acids |
Molecular Weight : | 36.410kDa inclusive of tags |
Source : | Wheat germ |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage buffer : | pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | GTAEEFTYIMKRLGRALVIGEVTSG GCQPPQTYHVDDTNLYLTIPTARSV GASDGSSWEGVGVTPHVVVPAEEAL ARAKEMLQHNQLRVKRSPGLQDH |
Sequence Similarities : | Belongs to the peptidase S41A family. |
Gene Name : | RBP3 retinol binding protein 3, interstitial [ Homo sapiens ] |
Official Symbol : | RBP3 |
Synonyms : | RBP3; retinol binding protein 3, interstitial; retinol-binding protein 3; D10S64; D10S65; D10S66; |
Gene ID : | 5949 |
mRNA Refseq : | NM_002900 |
Protein Refseq : | NP_002891 |
MIM : | 180290 |
Uniprot ID : | P10745 |
Chromosome Location : | 10q11.2 |
Function : | retinal binding; retinoid binding; serine-type peptidase activity; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionRBP3 contributes to the efficient transport and delivery of retinoids to photoreceptor cells, facilitating their uptake for visual processes.
Potential therapeutic strategies targeting RBP3 could address vision-related disorders involving retinoid metabolism, making it a promising focus for drug development.
RBP3 interacts with binding partners, including retinoids like 11-cis-retinal, influencing its role in retinoid transport and uptake.
RBP3 is predominantly localized within the retina, specifically in photoreceptor cells and the retinal pigment epithelium (RPE).
RBP3 actively regulates retinoid homeostasis and participates in the visual cycle, critical for maintaining optimal visual function.
Retinol-Binding Protein 3 (RBP3) plays a crucial role in supporting visual function and regulating retinoid metabolism.
Dysregulation or abnormal expression of RBP3 is associated with vision-related disorders such as retinitis pigmentosa.
Customer Reviews (3)
Write a reviewGel electrophoresis consistently displayed well-defined bands, affirming the product's purity and reliability.
Replicating results underscored the reliability and relevance of the product's effects.
The user-friendly design of the product made it accessible to researchers with varying levels of expertise.
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