Recombinant Human RBP3 Protein, His-tagged

• Cat.No.: RBP3-01H
• Product Overview: RBP3 Human Recombinant (321-630a.a) produced in E. coli is a single, non-glycosylated Polypeptide chain. RBP3 is fused to a 6 a.a His tag at N-terminal and is purified by proprietary chromatographic techniques.

Specification

• Description: Retinol-binding proteins (RBP) are a family of proteins with various functions. Retinol and retinoic acid play crucial roles in the modulation of gene expression and overall development of an embryo. However, deficit or excess of either one of these substances can cause early embryo mortality or developmental malformations. Regulation of transport and metabolism of retinol necessary for a successful pregnancy is accomplished via RBP. Retinol binding proteins have been identified within the uterus, embryo, and extraembryonic tissue of the bovine, ovine, and porcine, therefore RBP takes part in proper retinol exposure to the embryo and successful transport at the maternal-fetal interface.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Filtered White lyophilized (freeze-dried) powder.
• Purity: Greater than 95.0% as determined by SDS-PAGE.
• Storage: Lyophilized RBP3 although stable at room temperature for 3 weeks, should be stored desiccated below -18 centigrade. Upon reconstitution. Retinol Binding Protein-3 should be stored at 4 centigrade between 2-7 days and for future use below -18 centigrade.
  Please prevent freeze-thaw cycles.
• Storage Buffer: PBS, pH 7.4
• Reconstitution: It is recommended to reconstitute the lyophilized RBP3 in sterile distilled H2O not less than 100 μg/ml, which can then be further diluted to other aqueous solutions.
• Shipping: Shipped at Room temperature.

Gene Information

• Gene Name: RBP3 retinol binding protein 3 [ Homo sapiens (human) ]
• Official Symbol: RBP3
• Synonyms: RBP3; retinol binding protein 3; IRBP; RBPI; RP66; D10S64; D10S65; D10S66; retinol-binding protein 3; interphotoreceptor retinoid-binding protein; interstitial retinol binding protein 3; retinol binding protein 3, interstitial
• Gene ID: 5949
• mRNA Refseq: NM_002900
• Protein Refseq: NP_002891
• MIM: 180290
• UniProt ID: P10745

Reviews

06/15/2022

Gel electrophoresis consistently displayed well-defined bands, affirming the product's purity and reliability.

12/08/2018

Replicating results underscored the reliability and relevance of the product's effects.

09/07/2018

The user-friendly design of the product made it accessible to researchers with varying levels of expertise.

Q&As

How does RBP3 contribute to the efficient transport and delivery of retinoids to photoreceptor cells in the eye?

RBP3 contributes to the efficient transport and delivery of retinoids to photoreceptor cells, facilitating their uptake for visual processes.

Are there potential therapeutic strategies targeting RBP3 for vision-related disorders involving retinoid metabolism?

Potential therapeutic strategies targeting RBP3 could address vision-related disorders involving retinoid metabolism, making it a promising focus for drug development.

Are there known binding partners or receptors that interact with RBP3, influencing its role in retinoid transport and uptake?

RBP3 interacts with binding partners, including retinoids like 11-cis-retinal, influencing its role in retinoid transport and uptake.

In which ocular compartments is RBP3 predominantly localized, specifically within the retina?

RBP3 is predominantly localized within the retina, specifically in photoreceptor cells and the retinal pigment epithelium (RPE).

In what ways does RBP3 actively regulate retinoid homeostasis and participate in the visual cycle within the eye?

RBP3 actively regulates retinoid homeostasis and participates in the visual cycle, critical for maintaining optimal visual function.

What is the primary role of Retinol-Binding Protein 3 (RBP3) in supporting visual function and retinoid metabolism?

Retinol-Binding Protein 3 (RBP3) plays a crucial role in supporting visual function and regulating retinoid metabolism.

What vision-related disorders or conditions are associated with dysregulation or abnormal expression of RBP3?

Dysregulation or abnormal expression of RBP3 is associated with vision-related disorders such as retinitis pigmentosa.