Recombinant Human RBX1, His-tagged

• Cat.No.: RBX1-2227H
• Product Overview: Recombinant Human RBX1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Source: E.coli
• Species: Human
• Tag: His
• Protein length: 1-108aa
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: RBX1 ring-box 1, E3 ubiquitin protein ligase [ Homo sapiens ]
• Official Symbol: RBX1
• Synonyms: RBX1; ring-box 1, E3 ubiquitin protein ligase; ring box 1; E3 ubiquitin-protein ligase RBX1; BA554C12.1; regulator of cullins 1; RNF75; ROC1; ZYP protein; RING box protein 1; RING-box protein 1; RING finger protein 75; MGC1481; FLJ60363; MGC13357
• Gene ID: 9978
• mRNA Refseq: NM_014248
• Protein Refseq: NP_055063
• MIM: 603814
• UniProt ID: P62877
• Chromosome Location: 22q13.2
• Pathway: Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination and Proteasome degradation, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem; Circadian rhythm - mammal, organism-
• Function: NEDD8 ligase activity; ligase activity; metal ion binding; protein binding; contributes_to ubiquitin-protein ligase activity; zinc ion binding

Reviews

03/01/2020

Efficiency and precision, vital for research quality.

11/02/2019

Critical for decision-making, accelerates research productivity.

04/04/2017

Enhances research credibility, a cornerstone of our research.

Q&As

How does RBX1 contribute to proteasome-mediated degradation?

It facilitates the attachment of ubiquitin, directing proteins to the proteasome for breakdown.

What potential therapeutic applications arise from targeting RBX1 in diseases?

Targeting RBX1 offers potential for treating diseases with dysregulated protein turnover, including cancer.

What is the impact of altered RBX1 activity on cancer development?

Altered RBX1 activity is associated with cancer progression, influencing cell proliferation and survival.

What role does RBX1 play in cell cycle regulation?

RBX1 plays a role in cell cycle control by regulating the degradation of key cycle-related proteins.

How do genetic variations in RBX1 affect cellular processes?

Genetic mutations in RBX1 can lead to disruptions in protein turnover, affecting various cellular functions.

What is the primary role of RBX1 in protein ubiquitination?

RBX1, a RING-finger protein, is crucial for tagging proteins with ubiquitin, marking them for degradation.

How does RBX1 interact with other components of the ubiquitin-proteasome system?

RBX1 works with other ubiquitin-proteasome system components, orchestrating protein degradation.