RBX1
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Official Full Name
ring-box 1, E3 ubiquitin protein ligase
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Overview
This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.[provided by RefSeq, Sep 2010] -
Synonyms
RBX1; ring-box 1, E3 ubiquitin protein ligase; ROC1; RNF75; BA554C12.1; E3 ubiquitin-protein ligase RBX1; ZYP protein; RING box protein 1; RING-box protein 1; RING finger protein 75; regulator of cullins 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- T7
- Involved Pathway
- Protein Function
- Interacting Protein
RBX1 involved in several pathways and played different roles in them. We selected most pathways RBX1 participated on our site, such as Nucleotide excision repair, HIF- signaling pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with RBX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Nucleotide excision repair | COPS6;COPS7B;ERCC5;RPA2;INO80B;CCNH;COPS5;RAD23A;GTF2H2C_2 |
HIF- signaling pathway | CAMK2D;MAPK3;INSR;NOX1;EP300;RBX1;Il6ra;HK2;VEGFA |
Cell cycle | MSH4;STAG2;TSGA14;SKA2;CCNE1;SMC4;YWHAB;BUB1;SKP2 |
Oocyte meiosis | PPP2CB;YWHAG1;PPP1CAB;CPEB1;SMC3;ANAPC11;YWHAE1;CALM3B;PPP2R5D |
Ubiquitin mediated proteolysis | UBE2D1A;ANAPC1;NEDD4;SKP2;UBE2IA;UBE2U;SOCS3;TRIP12;TRAF6 |
Protein processing in endoplasmic reticulum | HSPA1B;RPN1;SKP1;LMAN2;HSPBP1;BCAP31;DNAJC3;RBX1;CUL1 |
Wnt signaling pathway | DKK4;WNT2B;FOSL1;RBX1;PPP3CB;WNT7A;NLK;GPC4;RAC3B |
TGF-beta signaling pathway | BMPR1AA;IFNG;LFT2;BMP7A;BMP8B;ACVR2AA;BMP7B;GDF6;GDF5 |
Circadian rhythm | BTRC;FBXW11;BHLHE40;RORA;PRKAB2;ARNTL;PRKAG2;PRKAA1;NPAS2 |
Pathways in cancer | GNG10;STAT5B;TRAF3;PRKACG;KITLG;ARNT2;PLCB4;AKT2;GNB4 |
Renal cell carcinoma | RAC1;TCEB2;GAB1;PAK1;RAP1B;TGFB3;FH1;PAK7;RBX1 |
RBX1 has several biochemical functions, for example, NEDD8 transferase activity, cullin family protein binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RBX1 itself. We selected most functions RBX1 had, and list some proteins which have the same functions with RBX1. You can find most of the proteins on our site.
Function | Related Protein |
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NEDD8 transferase activity | RBX1;UBE2F;RNF7;UBE2M |
cullin family protein binding | DCUN1D4;RBX1;DCUN1D1;KCTD17;ANAPC11;CCDC22;TCHP;PARK2;DCUN1D2A |
ligase activity | HUWE1;RNF152;UBE2D1B;LTN1;IRF2BP1;SIAH2L;RNF2;TRAF2;PJA1 |
protein binding | ATOX1;BBS4;MASP2;SIN3B;FIGNL1;BMP1;BMX;PRICKLE1;FAM164C |
protein complex binding | PRMT5;CRHR1;ST13;MYO7A;MYC;GNB1;ADM2;LCK;TRAF2 |
ubiquitin protein ligase activity | ARIH1L;UBE2Z;ITCHA;SMURF1;RBBP6;RAG1;RNF24;RNF144B;G2E3 |
ubiquitin protein ligase binding | GPR37;PRKACA;TRIB3;UBE2V1;FANCL;LYN;DERL1;FZD8;GGN |
contributes_to ubiquitin-protein transferase activity | DDB2;DTL;KLHL26;KBTBD2;KBTBD13;KLHL7;BACH1;GAN;BARD1 |
ubiquitin-ubiquitin ligase activity | PRPF19;UBOX5;ANAPC11;UBE2K;RBX1;STUB1;UBE4B;PPIL2;AMFR |
zinc ion binding | PIAS4A;OTUD7A;ZFML;TRIM32;C6AST4;NR4A1;TRIM3;CYHR1;SIRT3 |
RBX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RBX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RBX1.
CUL1; CUL4B
- Q&As
- Reviews
Q&As (7)
Ask a questionIt facilitates the attachment of ubiquitin, directing proteins to the proteasome for breakdown.
Targeting RBX1 offers potential for treating diseases with dysregulated protein turnover, including cancer.
Altered RBX1 activity is associated with cancer progression, influencing cell proliferation and survival.
RBX1 plays a role in cell cycle control by regulating the degradation of key cycle-related proteins.
Genetic mutations in RBX1 can lead to disruptions in protein turnover, affecting various cellular functions.
RBX1, a RING-finger protein, is crucial for tagging proteins with ubiquitin, marking them for degradation.
RBX1 works with other ubiquitin-proteasome system components, orchestrating protein degradation.
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