Recombinant Human RBX1 protein, GST-tagged

• Cat.No.: RBX1-3416H
• Product Overview: Recombinant Human RBX1 protein(P62877)(1-108aa), fused to N-terminal GST tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: GST
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
  If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Molecular Mass: 39.3 kDa
• Protein length: 1-108aa
• AA Sequence: MAAAMDVDTPSGTNSGAGKKRFEVK KWNAVALWAWDIVVDNCAICRNHIM DLCIECQANQASATSEECTVAWGVC NHAFHFHCISRWLKTRQVCPLDNRE WEFQKYGH
• Purity: Greater than 90% as determined by SDS-PAGE.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%.

Gene Information

• Gene Name: RBX1 ring-box 1, E3 ubiquitin protein ligase [ Homo sapiens ]
• Official Symbol: RBX1
• Synonyms: RBX1; ring-box 1, E3 ubiquitin protein ligase; ring box 1; E3 ubiquitin-protein ligase RBX1; BA554C12.1; regulator of cullins 1; RNF75; ROC1; ZYP protein; RING box protein 1; RING-box protein 1; RING finger protein 75; MGC1481; FLJ60363; MGC13357
• Gene ID: 9978
• mRNA Refseq: NM_014248
• Protein Refseq: NP_055063
• MIM: 603814
• UniProt ID: P62877

Reviews

03/01/2020

Efficiency and precision, vital for research quality.

11/02/2019

Critical for decision-making, accelerates research productivity.

04/04/2017

Enhances research credibility, a cornerstone of our research.

Q&As

How does RBX1 contribute to proteasome-mediated degradation?

It facilitates the attachment of ubiquitin, directing proteins to the proteasome for breakdown.

What potential therapeutic applications arise from targeting RBX1 in diseases?

Targeting RBX1 offers potential for treating diseases with dysregulated protein turnover, including cancer.

What is the impact of altered RBX1 activity on cancer development?

Altered RBX1 activity is associated with cancer progression, influencing cell proliferation and survival.

What role does RBX1 play in cell cycle regulation?

RBX1 plays a role in cell cycle control by regulating the degradation of key cycle-related proteins.

How do genetic variations in RBX1 affect cellular processes?

Genetic mutations in RBX1 can lead to disruptions in protein turnover, affecting various cellular functions.

What is the primary role of RBX1 in protein ubiquitination?

RBX1, a RING-finger protein, is crucial for tagging proteins with ubiquitin, marking them for degradation.

How does RBX1 interact with other components of the ubiquitin-proteasome system?

RBX1 works with other ubiquitin-proteasome system components, orchestrating protein degradation.