Recombinant Human RCVRN Protein (Gly2-Ala200), His tagged

• Cat.No.: RCVRN-6160H
• Product Overview: Recombinant human RCVRN (Gly2-Ala200) fused with His tag was expressed in E. coli.

Specification

• Description: Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells. Modulates light sensitivity of cone photoreceptor in dark and dim conditions. In response to high Ca2+ levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin. Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells. Improves rod photoreceptor sensitivity in dim light and mediates response of rod photoreceptors to facilitate detection of change and motion in bright light.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 23.73 kDa
• Protein Length: Gly2-Ala200
• Purity: > 90 % as determined by SDS-PAGE
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: RCVRN recoverin [ Homo sapiens (human) ]
• Official Symbol: RCVRN
• Synonyms: RCVRN; recoverin; RCV1; cancer associated retinopathy antigen; cancer-associated retinopathy protein
• Gene ID: 5957
• mRNA Refseq: NM_002903
• Protein Refseq: NP_002894
• MIM: 179618
• UniProt ID: P35243

Reviews

02/16/2020

Whether investigating metabolic pathways, studying enzymatic activity, or exploring drug targets, this protein offers versatility and reliability, allowing for accurate and meaningful data collection.

05/29/2018

In addition to the remarkable protein quality, the manufacturer provides excellent technical support, proving to be a valuable resource when troubleshooting experimental challenges.

06/24/2016

Incorporating this protein into scientific investigations undoubtedly enhances the reliability and effectiveness of research endeavors.

Q&As

Are there any specific populations that may benefit more from RCVRN-targeted therapies?

Individuals with genetic mutations affecting RCVRN and those with early-stage retinal diseases may potentially benefit more from targeted therapies.

How does the expression of RCVRN change with age, and does this have implications for age-related vision disorders?

The expression of RCVRN may change with age, and understanding these changes can provide insights into age-related vision disorders.

How is the level of RCVRN expression correlated with the progression of certain retinal disorders?

Changes in RCVRN expression levels may correlate with the progression of retinal disorders, serving as a potential indicator of disease severity.

Are there ongoing clinical trials exploring the use of RCVRN-based therapies?

Some clinical trials are investigating the safety and efficacy of gene therapies targeting the RCVRN gene for treating specific eye conditions.

How might the manipulation of RCVRN expression offer therapeutic benefits for patients with vision impairments?

Modulating RCVRN expression could potentially restore or enhance photoreceptor function, providing therapeutic benefits for vision-impaired individuals.