Recombinant Human Relaxin 2

• Cat.No.: RLN2-173H
• Product Overview: Recombinant Relaxin-2 is a nonglycosylated 6.0 kDa disulfide linked heterodimeric protein consisting of a 24 amino acid A-chain and a 29 amino acid B-chain.

Specification

• Cat. No.: RLN2-173H
• Description: Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The active form of the protein encoded by this gene consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. Alternative splicing of this gene results in multiple transcript variants.
• Source: E. coli
• AA Sequence: A-Chain: QLYSALANKC CHVGCTKRSL ARFC; B-Chain: DSWMEEVIKL CGRELVRAQI AICGMSTWS
• Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses.
• Biological Activity: Data Not Available
• Note: Research Use Only. Not for use in diagnostic or therapeutic procedures.
• OfficialSymbol: RLN2

Gene Information

• Gene Name: RLN2 relaxin 2 [ Homo sapiens ]
• Synonyms: RLN2; relaxin 2; H2; RLXH2; bA12D24.1.1; bA12D24.1.2; prorelaxin H2; Prorelaxin H2; OTTHUMP00000021027; relaxin 2 (H2); relaxin H2; relaxin, ovarian, of pregnancy; RLXH2; bA12D24.1.1; bA12D24.1.2
• Gene ID: 6019
• mRNA Refseq: NM_005059
• Protein Refseq: NP_005050
• MIM: 179740
• UniProt ID: P04090
• Chromosome Location: 9p24.1
• Pathway: Class A/1 (Rhodopsin-like receptors); GPCR downstream signaling; G alpha (s) signalling events
• Function: hormone activity

Reviews

01/09/2021

Superior quality—this protein is a must-have in our lab for consistent outcomes.

04/24/2020

The quality control is evident in the data precision we achieve.

10/14/2019

Fast delivery! Got this product promptly, no delays, intact packaging.

Q&As

What are the molecular mechanisms by which RLN-2 induces vasodilation in blood vessels?

RLN-2 induces vasodilation by activating nitric oxide (NO) signaling pathways, promoting smooth muscle relaxation and increased blood flow.

How does RLN-2 interact with the immune system, and what are its immunomodulatory effects?

RLN-2 has immunomodulatory effects, influencing cytokine production, immune cell migration, and contributing to the regulation of inflammatory responses.

Can you elaborate on the molecular basis of RLN-2's anti-fibrotic effects in various tissues?

RLN-2 exerts anti-fibrotic effects by inhibiting myofibroblast differentiation, reducing collagen deposition, and modulating fibrotic signaling pathways.

How does RLN-2 influence collagen synthesis and degradation in connective tissues?

RLN-2 inhibits collagen synthesis and enhances collagen degradation by modulating the activity of enzymes involved in collagen turnover.

How does RLN-2 influence extracellular matrix remodeling, and what enzymes are involved in this process?

RLN-2 promotes extracellular matrix remodeling by upregulating matrix metalloproteinases (MMPs) and inhibiting tissue inhibitors of metalloproteinases (TIMPs).