Recombinant Human RGN, His-tagged

• Cat.No.: RGN-3642H
• Product Overview: Recombinant human RGN protein, fused to His-tag at N-terminus, was expressed in E.coli (1-299 aa).

Specification

• Cat. No.: RGN-3642H
• Description: RGN (Regucalcin) belongs to the SMP-30/CGR1 family. This protein is Ca (2+)-binding protein that does not contain EF-hand motif of Ca (2+)-binding domain. RGN plays a pivotal role in the keep of intracellular Ca2+ homeostasis due to activating Ca2+ pump enzymes in the plasma membrane (basolateral membrane), microsomes (endoplasmic reticulum) and mitochondria of many cells. Also, it plays a multifunctional role in the regulation of cell functions in liver, kidney cortex, heart and brain and a suppressor protein for cell signaling systems in many cell types.
• Form: Liquid. In 20mM Tris-HCl, pH8.0, 2M Urea, 20%Glycerol
• Molecular Weight: 35.4kDa (319aa)
• Purity: > 85% by SDS - PAGE
• Concentration: 0.5mg/ml (determined by Bradford assay)
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MSSIKIECVL PENCRCGESP VWEEVSNSLL FVDIPAKKVC RWDSFTKQVQ RVTMDAPVSS VALRQSGGYV ATIGTKFCAL NWKEQSAVVL ATVDNDKKNN RFNDGKVDPA GRYFAGTMAE ETAPAVLERH QGALYSLFPD HHVKKYFDQV DISNGLDWSL DHKIFYYIDS LSYSVDAFDY DLQTGQISNR RSVYKLEKEE QIPDGMCIDA EGKLWVACYN GGRVIRLDPV TGKRLQTVKL PVDKTTSCCF GGKNYSEMYV TCARDGMDPE GLLRQPEAGG IFKITGLGVK GIAPYSYAG
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Pathways: Ascorbate and aldarate metabolism; Metabolic pathways; Pentose phosphate pathway

Gene Information

• Gene Name: RGN regucalcin (senescence marker protein-30) [ Homo sapiens ]
• Official Symbol: RGN
• Synonyms: RGN; RC; GNL; SMP30; regucalcin (senescence marker protein-30); regucalcin; SMP-30; gluconolactonase; OTTHUMP00000023195; OTTHUMP00000023196; senescence marker protein 30; senescence marker protein-30; EC 3.1.1.17; Gluconolactonase
• Gene ID: 9104
• mRNA Refseq: NM_004683
• Protein Refseq: NP_004674
• MIM: 300212
• UniProt ID: Q15493
• Chromosome Location: Xp11.3
• Function: calcium ion binding; enzyme regulator activity; gluconolactonase activity; hydrolase activity; zinc ion binding

Reviews

12/27/2020

Precise results, highly recommended for research.

11/09/2019

Efficient service, great for protein analysis.

06/12/2017

Accurate data, crucial for our experiments.

Q&As

What role does RGN protein play in tissue regeneration and repair?

RGN plays a key role in tissue repair and regeneration, potentially by promoting cell differentiation and proliferation.

What factors regulate the expression and activity of RGN protein?

Both exogenous and endogenous factors can regulate RGN's expression and activity, including environmental stress and drug interactions.

How does RGN protein expression vary across different types of cancer?

RGN expression varies in different cancers, reflecting its complex role in cancer development.

What physiological processes are affected by heterogeneous expression of RGN protein?

Different levels of RGN expression impact cellular growth regulation, metabolic balance, and differentiation processes.

How do structural changes in RGN protein affect its biological function?

Minor structural changes can significantly alter RGN's activity, affecting its biological function.

How does RGN protein interact with other proteins to affect cell signaling?

RGN influences various intracellular signaling pathways through interactions with other proteins.

What is the effect of RGN protein on cell proliferation and apoptosis?

RGN can either promote or inhibit cell proliferation and apoptosis by modulating specific signaling pathways.