Recombinant Human RGN, His-tagged

• Cat.No.: RGN-30488TH
• Product Overview: Recombinant full length Human Regucalcin with an N terminal His tag; 319 amino acids with the tag; mwt: 35.4 kDa.

Specification

• Description: The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in two transcript variants having different 5 UTRs, but encoding the same protein.
• Protein length: 299 amino acids
• Conjugation: HIS
• Molecular Weight: 35.400kDa inclusive of tags
• Source: E. coli
• Form: Liquid
• Purity: by SDS-PAGE
• Storage buffer: pH: 8.00Constituents:0.32% Tris HCl, 20% Glycerol, 1.2% Urea
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMSSIK IECVLPENCRCGESPVWEEVSNSLL FVDIPAKKVCRWDSFTKQVQRVTMD APVSSVALRQSGGYVATIGTKFCAL NWKEQSAVVLATVDNDKKNNRFNDG KVDPAGRYFAGTMAEETAPAVLERH QGALYSLFPDHHVKKYFDQVDISNG LDWSLDHKIFYYIDSLSYSVDAFDY DLQTGQISNRRSVYKLEKEEQIPDG MCIDAEGKLWVACYNGGRVIRLDPV TGKRLQTVKLPVDKTTSCCFGGKNY SEMYVTCARDGMDPEGLLRQPEAGG IFKITGLGVKGIAPYSYAG
• Sequence Similarities: Belongs to the SMP-30/CGR1 family.

Gene Information

• Gene Name: RGN regucalcin (senescence marker protein-30) [ Homo sapiens ]
• Official Symbol: RGN
• Synonyms: RGN; regucalcin (senescence marker protein-30); regucalcin; RC; senescence marker protein 30; SMP30
• Gene ID: 9104
• mRNA Refseq: NM_004683
• Protein Refseq: NP_004674
• MIM: 300212
• Uniprot ID: Q15493
• Chromosome Location: Xp11.3
• Pathway: Ascorbate and aldarate metabolism, organism-specific biosystem; Ascorbate and aldarate metabolism, conserved biosystem; Ascorbate biosynthesis, animals, glucose-1P => ascorbate, organism-specific biosystem; Ascorbate biosynthesis, animals, glucose-1P =>
• Function: calcium ion binding; calcium ion binding; enzyme regulator activity; gluconolactonase activity; hydrolase activity

Reviews

12/27/2020

Precise results, highly recommended for research.

11/09/2019

Efficient service, great for protein analysis.

06/12/2017

Accurate data, crucial for our experiments.

Q&As

What role does RGN protein play in tissue regeneration and repair?

RGN plays a key role in tissue repair and regeneration, potentially by promoting cell differentiation and proliferation.

What factors regulate the expression and activity of RGN protein?

Both exogenous and endogenous factors can regulate RGN's expression and activity, including environmental stress and drug interactions.

How does RGN protein expression vary across different types of cancer?

RGN expression varies in different cancers, reflecting its complex role in cancer development.

What physiological processes are affected by heterogeneous expression of RGN protein?

Different levels of RGN expression impact cellular growth regulation, metabolic balance, and differentiation processes.

How do structural changes in RGN protein affect its biological function?

Minor structural changes can significantly alter RGN's activity, affecting its biological function.

How does RGN protein interact with other proteins to affect cell signaling?

RGN influences various intracellular signaling pathways through interactions with other proteins.

What is the effect of RGN protein on cell proliferation and apoptosis?

RGN can either promote or inhibit cell proliferation and apoptosis by modulating specific signaling pathways.